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International Journal of Innovation and Applied Studies
ISSN: 2028-9324     CODEN: IJIABO     OCLC Number: 828807274     ZDB-ID: 2703985-7
 
 
Thursday 12 December 2019

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Evaluation the efficiency of Probiotic Iraqi Product and Saccharomyces boulardii in Detoxification of Zearalenone In vivo


[ تقييم كفاءة المنتوج الحيوي المنتوج العراقي وخميرة بولاردي في ازالة السم الفطري الزيرالينون داخل جسم الكائن الحي ]

Volume 25, Issue 4, March 2019, Pages 1225–1234

 Evaluation the efficiency of Probiotic Iraqi Product and Saccharomyces boulardii in Detoxification of Zearalenone In vivo

Shatha Ali Shafiq1 and Mushaq Talib Kareem2

1 Department of Biology, College of Science, Mustansiriyah University, Baghdad, Iraq
2 Mustansiriyah University, College of Science, Department of Biology, Baghdad, Iraq

Original language: Arabic

Received 14 December 2018

Copyright © 2019 ISSR Journals. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract


The present study was conducted to investigate the biological degradation of Zearalenone using by Iraqi probiotic 2% (w/v) and yeast filtrate of Saccharomyces boulardii using one of the mammalian system (white mouse ) which had an active influence in removing or reduction of toxic effects of mycotoxin Zearalenone on liver and kidney tissues of males white mice that extracted from fungal isolate Fusarium graminearum produced Zearalenone at concentration (2 mg / kg body weight) . As observed a clear improvement in liver and kidney tissues for group of mice that fed contaminated diet by Fusarium graminearum produced Zearalenone with Iraqi probiotic and yeast filtrate compared with positive control ( group of mice fed contaminated diet by Fusarium graminearum produced Zearalenone ) that caused the histological changes in liver and kidney tissues ,which represented by congestion vascular with necrosis and degeneration in hepatic cells in addition to reduction in glycoprotein granules. While, the histological changes in kidney tissue included congestion vascular and degeneration in distal and proximal tubules. The results of liver enzymes showed significant differences in positive group for three enzymes ALS , ALT and ALP reached ( 15.66, 14.66, 25.66 ) IU/ L respectively, compared with negative control (group of mice did not fed contaminated diet by Fusarium graminearum produced Zearalenone ) which reached for three enzymes ALS , ALT and ALP (15.66,22.00,13.33) IU/ L respectively. However, the results of the interaction between mice fed contaminated diet by Fusarium graminearum produced Zearalenone with Iraqi probiotic and yeast filtrate were shown significant increasing for ALS, ALT, ALP enzymes in addition to urea concentrations in kidney tissue compared with positive control.

Author Keywords: Saccharomyces boulardii, Detoxification, Zearalenone, Iraqi probiotic product.


Abstract: (arabic)


هدفت الدراسة الحالية دراسة التحطيم الاحيائي لسم الزيرالينون بواسطة المعزز الحيوي المنتتوج العراقي بتركيز (2%) وزن/حجم وراشح خميرة بولاردي داخل جسم الكائن الحي باستخدام احد انظمة اللبائن ( الفأر الابيض ) واللذان كان لهما الاثر الفــــعال والمعـــنوي في ازالة او اختزال التاثيرات السمية لسم الزيرالينون في نسيجي الكبد والكلى، اذ لوحــــظ تحسن واضح في خــــلايا نسيج الكبد والكلى لمجموعة الفئران التي تم تغذيتـــها عــــــلى العـــليقة المـــلوثة بالفــــطر فيوزاريوم جرامينياريوم المنتج لسم الزيرالينون وبتركيز(2)ملغم/كغم مع المعزز الحيوي وراشح الخميرة مقارنة مع ما احــدثته السيطرة الموجبة والمتمثلة بمجموعة الفئران التي تغذت على العليقة الملوثة بفـــطر فيوزاريوم جرامينياريوم المنتج لسم الزيرالينون من تغيرات نسيجية في نسيجي الكبد والكلى تمـــثلت باحتقان في الاوعية الدموية مع تنخر وتنكس في الخلايا الكـــبدية وقلة حبيـــبات الكلايكوبروتين، بينما تضمنت التغيرات النسيجية في نسيج الكلى باحـــتقان دموي في الاوعية الدموية مع وجود تنكسات في الخلايا المبطنة الدانية والقاصـــية .

Author Keywords: خميرة بولاردي، إزالة السموم، زيرالينون، منتج بروبيوتيك عراقي.


How to Cite this Article


Shatha Ali Shafiq and Mushaq Talib Kareem, “Evaluation the efficiency of Probiotic Iraqi Product and Saccharomyces boulardii in Detoxification of Zearalenone In vivo,” International Journal of Innovation and Applied Studies, vol. 25, no. 4, pp. 1225–1234, March 2019.