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International Journal of Innovation and Applied Studies
ISSN: 2028-9324     CODEN: IJIABO     OCLC Number: 828807274     ZDB-ID: 2703985-7
 
 
Tuesday 10 December 2019

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Anti-cyclic citrullinated peptide antibodies and association with HLA alleles in Moroccan patients with systemic lupus erythematosus


Volume 25, Issue 3, February 2019, Pages 1132–1136

 Anti-cyclic citrullinated peptide antibodies and association with HLA alleles in Moroccan patients with systemic lupus erythematosus

Ouahiba Bhallil1, Aicha Ibrahimi2, Samira EL FAKIR3, Naima Ouzeddoun4, Rabia Bayahia5, and Malika Essakalli6

1 Faculty of Medicine and Pharmacy, University Mohamed V, Rabat, Morocco
2 Department of Nephrology, Dialysis and Kidney Transplantation, CHU Ibn Sina, Rabat, Morocco
3 Laboratoire d’Epidémiologie, Recherche Clinique et Santé Communautaire, Faculté de Médecine et de Pharmacie de Fès, Université Sidi Mohamed Ben Abdellah, Fès, Morocco
4 Service de Néphrologie, faculté de médecine et de pharmacie, université Mohamed V, hôpital Ibn Sina (Avicenne), Morocco
5 Service de Néphrologie, faculté de médecine et de pharmacie, université Mohamed V, hôpital Ibn Sina (Avicenne), Morocco
6 Faculty of Medicine and Pharmacy, University Mohamed V, Rabat, Morocco

Original language: English

Received 25 December 2018

Copyright © 2019 ISSR Journals. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract


Systemic Lupus Erythematosus (SLE) patients may have arthritis in early stages of the disease. This study aims to investigate the prevalence of anti-CCP in SLE patients from Morocco and its association with HLA class II alleles. Anti-cyclic citrullinated peptide antibodies (Anti-CCP) were measured using ELISA in 88 SLE patients with and without arthritis. Levels ≥ 25 units/ ml defined a positive test of anti-CCP antibodies. Positive anti-CCP was detected in 8 % of SLE patients whose 85.71% % with arthritis and 14.28% without arthritis. The mean titer of anti-CCP antibodies in the SLE group was 83.75 U/ml. HLA class II alleles typing was performed by polymerase chain reaction-sequence-specific primers (PCR-SSP). We found an increase of HLA-DRB1*04 frequency and decrease of DRB1*07 frequency in SLE patients with anti-CCP positive. In the Moroccan population we demonstrated the presence of high titer of anti-CCP in SLE. Results from our study also identified the frequency of HLA-DRB1*04 allele is increased in SLE with anti-CCP positive.

Author Keywords: Anti-cyclic citrullinated peptide antibodies, Systemic Lupus Erythematosus, Human leukocyte antigen, arthritis, Moroccan population.


How to Cite this Article


Ouahiba Bhallil, Aicha Ibrahimi, Samira EL FAKIR, Naima Ouzeddoun, Rabia Bayahia, and Malika Essakalli, “Anti-cyclic citrullinated peptide antibodies and association with HLA alleles in Moroccan patients with systemic lupus erythematosus,” International Journal of Innovation and Applied Studies, vol. 25, no. 3, pp. 1132–1136, February 2019.