[ Etude comparative de la variabilité de la Procalcitonine et de la C-Réactive Protéine dans le Syndrome Respiratoire Aigu Sévère à Coronavirus-2SARS-CoV-2, chez les patients hospitalisés en réanimation ]
Volume 34, Issue 1, October 2021, Pages 74–80
Asmaa Morjan1, Omari Mohamed2, Elmernissi Zakaria3, and Nabiha Kamal4
1 Laboratoire de biochimie, CHU Ibn Rochd, Casablanca, Morocco
2 Faculté des sciences juridiques, économiques et sociales, Mohammedia, Université Hassan II, Casablanca, Morocco
3 Laboratoire de biochimie, CHU Ibn Rochd de Casablanca, Morocco
4 Laboratoire de biochimie, CHU Ibn Rochd, Casablanca, Morocco
Original language: French
Copyright © 2021 ISSR Journals. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
The Covid-19 outbreak is a global pandemic officially declared on March 12, 2020, with more than two million deaths. To assess the role of Procalcitonin as a biomarker of the specific inflammatory response and C-Réactive Protein as a stable and early biomarker of acute inflammation in pathogenesis and disease severity, we conducted a prospective descriptive study in the biochemistry laboratory of the Ibn Rochd University Of Casablanca Morocco in Covid-19 positive patients hospitalized in resuscitation. These biomarkers were abnormally increased in most of these patients. All of the patients who died had a positive admission CRP that would support a positive correlation between the increase in CRP and the severity of infection, without any correlation between CRP values in our study population with age or sex. The follow-up of the PRC could reflect its severity and should be used as a key monitoring indicator for Covid-19. PCT values at admission can predict the progression to a severe form of the disease. However, its synthesis is inhibited by interferon (INF) -γ, whose concentration increases during Coronavirus-2 infection.
Author Keywords: Covid-19, Resuscitation, PCT, CRP, Variability.
Volume 34, Issue 1, October 2021, Pages 74–80
Asmaa Morjan1, Omari Mohamed2, Elmernissi Zakaria3, and Nabiha Kamal4
1 Laboratoire de biochimie, CHU Ibn Rochd, Casablanca, Morocco
2 Faculté des sciences juridiques, économiques et sociales, Mohammedia, Université Hassan II, Casablanca, Morocco
3 Laboratoire de biochimie, CHU Ibn Rochd de Casablanca, Morocco
4 Laboratoire de biochimie, CHU Ibn Rochd, Casablanca, Morocco
Original language: French
Copyright © 2021 ISSR Journals. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
The Covid-19 outbreak is a global pandemic officially declared on March 12, 2020, with more than two million deaths. To assess the role of Procalcitonin as a biomarker of the specific inflammatory response and C-Réactive Protein as a stable and early biomarker of acute inflammation in pathogenesis and disease severity, we conducted a prospective descriptive study in the biochemistry laboratory of the Ibn Rochd University Of Casablanca Morocco in Covid-19 positive patients hospitalized in resuscitation. These biomarkers were abnormally increased in most of these patients. All of the patients who died had a positive admission CRP that would support a positive correlation between the increase in CRP and the severity of infection, without any correlation between CRP values in our study population with age or sex. The follow-up of the PRC could reflect its severity and should be used as a key monitoring indicator for Covid-19. PCT values at admission can predict the progression to a severe form of the disease. However, its synthesis is inhibited by interferon (INF) -γ, whose concentration increases during Coronavirus-2 infection.
Author Keywords: Covid-19, Resuscitation, PCT, CRP, Variability.
Abstract: (french)
La flambée de la Covid-19 constitue une pandémie mondiale déclarée officiellement le 12 mars 2020 dont le nombre de décès a dépassé les deux millions. Pour évaluer le rôle de la Procalcitonine comme biomarqueur de la réponse inflammatoire spécifique et la C-Réactive Protéine comme biomarqueur stable et précoce de l’inflammation aigue dans la pathogénie et la gravité de la maladie, nous avons mené une étude prospective à visée descriptive au sein du laboratoire de biochimie du CHU Ibn Rochd de Casablanca Maroc chez les patients Covid-19 positifs hospitalisés en réanimation. Ces deus biomarqueurs ont étaient anormalement augmentés chez la plupart de ces patients. La totalité des patients décédés, avaient une CRP positive à l’admission qui serait en faveur d’une corrélation positive entre l’augmentation de la CRP et la gravité de l’infection, sans aucune corrélation entre les valeurs de la CRP chez notre population d’étude avec l’âge ou le sexe. Le suivi de la CRP pourrait refléter sa gravité et devrait être utilisé comme indicateur clé de surveillance de la Covid-19. Les valeurs de la PCT à l’admission peuvent prédire l'évolution vers une forme sévère de la maladie. Néanmoins, sa synthèse est inhibée par l'interféron (INF) -γ, dont la concentration augmente au cours de l’infection au Coronavirus-2.
Author Keywords: Covid-19, réanimation, PCT, CRP, variabilité.
How to Cite this Article
Asmaa Morjan, Omari Mohamed, Elmernissi Zakaria, and Nabiha Kamal, “Comparative study of procalcitonin and C-Reactive Protein variability in Coronavirus-2SARS-CoV-2 Acute Respiratory Syndrome in hospitalized patients in resuscitation,” International Journal of Innovation and Applied Studies, vol. 34, no. 1, pp. 74–80, October 2021.
