[ Evaluation de la qualité du cotrimoxazole 480mg comprimé générique vendu dans la ville de Douala (Cameroun) ]
Volume 15, Issue 4, May 2016, Pages 926–935
Emmanuel NNANGA NGA1, Y.L.T. TABI OMBGA2, M.C. KIDIK POUKA3, D. VANDI4, D.E. TSALA5, L. SIDJUI6, and Emmanuel A. MPONDO MPONDO7
1 Department of galenical Pharmacy and pharmaceutical legislation, Faculty of Medicine and Biological Sciences, the University of Yaoundé I. PO. Box: 1364, Yaoundé,Department of Pharmaceutical Science, Faculty of Medicine and Pharmaceutical Science ; the University of Douala, PO. Box : 2701, Douala, Institute of Medical Research and Medicinal Plants Studies, PO.Box:6163. Yaoundé, Cameroon
2 Department of galenical Pharmacy and pharmaceutical legislation, Faculty of Medicine and Biological Sciences, the University of Yaoundé I. PO. Box: 1364, Yaoundé, Cameroon
3 Department of Pharmaceutical Science, Faculty of Medicine and Pharmaceutical Science ; the University of Douala, PO. Box : 2701, Douala, Cameroon
4 Department of Pharmaceutical Science, Faculty of Medicine and Pharmaceutical Science ; the University of Douala, PO. Box : 2701, Douala, Cameroon
5 FAC SCES.DEPT SC ; The university of Maroua, Po. Box: 814, Maroua, Cameroon
6 Institute of Medical Research and Medicinal Plants Studies, PO.Box:6163. Yaoundé, Cameroon
7 Department of Pharmaceutical Science, Faculty of Medicine and Pharmaceutical Science, University of Douala, PO. Box : 2701, Douala, Cameroun
Original language: French
Copyright © 2016 ISSR Journals. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Cotrimoxazole is an association of two anti-infectives Sulfamethoxazole and Trimethoprim. It is a broad-spectrum antibiotic active against a wide range of microorganism (bacteria, fungi and protozoa). It is also used for the prevention of opportunistic infections in HIV-AIDS patients when the l CD4 level is between 350-500/mm3. For this reason, it is necessary to ensure the quality of the medicine administered to our population. The purpose of the present study was to assess the quality of the generic Cotrimoxazole 480 mg tablets marketed in the Douala city. A total of 37 lots of drugs were analysed, six (6) collected in the private organizations, seven (7) in the public sector and twenty-fourth (24) in the illegal market using the cluster sampling poll method. These drugs were therefore submitted to standards pharmaco-technical and physico-chemical tests. Accordingly, the tests of disintegration, hardness, friability, mass uniformity, dimension uniformity, identification and the dosage of the active compounds demonstrated 33% of non-compliance in the private sector, 86% in the public sector and 79% in the illegal sector. In conclusion, the study revealed that non-conformities affected the official sector (private and public) as well as the illegal in Douala market.
Author Keywords: cotrimoxazole, quality, Douala, market.
Volume 15, Issue 4, May 2016, Pages 926–935
Emmanuel NNANGA NGA1, Y.L.T. TABI OMBGA2, M.C. KIDIK POUKA3, D. VANDI4, D.E. TSALA5, L. SIDJUI6, and Emmanuel A. MPONDO MPONDO7
1 Department of galenical Pharmacy and pharmaceutical legislation, Faculty of Medicine and Biological Sciences, the University of Yaoundé I. PO. Box: 1364, Yaoundé,Department of Pharmaceutical Science, Faculty of Medicine and Pharmaceutical Science ; the University of Douala, PO. Box : 2701, Douala, Institute of Medical Research and Medicinal Plants Studies, PO.Box:6163. Yaoundé, Cameroon
2 Department of galenical Pharmacy and pharmaceutical legislation, Faculty of Medicine and Biological Sciences, the University of Yaoundé I. PO. Box: 1364, Yaoundé, Cameroon
3 Department of Pharmaceutical Science, Faculty of Medicine and Pharmaceutical Science ; the University of Douala, PO. Box : 2701, Douala, Cameroon
4 Department of Pharmaceutical Science, Faculty of Medicine and Pharmaceutical Science ; the University of Douala, PO. Box : 2701, Douala, Cameroon
5 FAC SCES.DEPT SC ; The university of Maroua, Po. Box: 814, Maroua, Cameroon
6 Institute of Medical Research and Medicinal Plants Studies, PO.Box:6163. Yaoundé, Cameroon
7 Department of Pharmaceutical Science, Faculty of Medicine and Pharmaceutical Science, University of Douala, PO. Box : 2701, Douala, Cameroun
Original language: French
Copyright © 2016 ISSR Journals. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Cotrimoxazole is an association of two anti-infectives Sulfamethoxazole and Trimethoprim. It is a broad-spectrum antibiotic active against a wide range of microorganism (bacteria, fungi and protozoa). It is also used for the prevention of opportunistic infections in HIV-AIDS patients when the l CD4 level is between 350-500/mm3. For this reason, it is necessary to ensure the quality of the medicine administered to our population. The purpose of the present study was to assess the quality of the generic Cotrimoxazole 480 mg tablets marketed in the Douala city. A total of 37 lots of drugs were analysed, six (6) collected in the private organizations, seven (7) in the public sector and twenty-fourth (24) in the illegal market using the cluster sampling poll method. These drugs were therefore submitted to standards pharmaco-technical and physico-chemical tests. Accordingly, the tests of disintegration, hardness, friability, mass uniformity, dimension uniformity, identification and the dosage of the active compounds demonstrated 33% of non-compliance in the private sector, 86% in the public sector and 79% in the illegal sector. In conclusion, the study revealed that non-conformities affected the official sector (private and public) as well as the illegal in Douala market.
Author Keywords: cotrimoxazole, quality, Douala, market.
Abstract: (french)
Le Cotrimoxazole est une association de deux anti-infectieux le Sulfaméthoxazole et le Triméthoprime. C’est un antibiotique à large spectre actif contre une gamme variée de microorganisme (bactéries, mycoses et protozoaires). Il est aussi utilisé pour la prévention des infections opportunistes chez les patients infectés par le VIH-SIDA lorsque le taux de CD4 est dans l’intervalle de 350-500/mm3. Pour cela, il est nécessaire de s’assurer de la qualité du médicament administré à la population. Le but de notre étude est d’évaluer la qualité du Cotrimoxazole 480mg comprimé générique disponible dans la ville de Douala. Au total 37 lots de médicaments ont été analysés soit six (6) prélevés dans le secteur privé, sept (7) dans le secteur public et vingt-quatre (24) dans le secteur illicite selon une méthode d’échantillonnage par sondage en grappe. Puis soumis aux tests pharmaco-techniques et physico-chimiques. Au vu des résultats, pour ce qui concerne l’étiquetage, l’examen visuel, les tests de désagrégation, dureté, friabilité, uniformité de masse, uniformité des dimensions identification et le dosage, nous avons obtenu 33% de non-conformité dans le secteur privé, 86% dans le secteur public et 79% dans le secteur illicite. Au terme de notre travail, il ressort que les non-conformités touchent à la fois le secteur officiel (privé et public) et illicite.
Author Keywords: Cotrimoxazole, qualité, Douala, marché.
How to Cite this Article
Emmanuel NNANGA NGA, Y.L.T. TABI OMBGA, M.C. KIDIK POUKA, D. VANDI, D.E. TSALA, L. SIDJUI, and Emmanuel A. MPONDO MPONDO, “Quality assessment of sample of generic cotrimoxazole tablets (480mg) marketed in Douala (Cameroon),” International Journal of Innovation and Applied Studies, vol. 15, no. 4, pp. 926–935, May 2016.
