Volume 18, Issue 3, November 2016, Pages 711–720
Lahcen Elmoumou1 and Hassan Fellah2
1 Immunology Laboratory, Faculty of Medicine and Pharmacy, Casablanca, Morocco
2 Immunology Laboratory, Faculty of Medicine and Pharmacy, Casablanca, Morocco
Original language: English
Copyright © 2016 ISSR Journals. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
The progressive loss of kidney function is associated with an inflammatory state and functional defects of the innate and adaptive immune system. The combined effects of increased activation and immune dysfunction could explain the susceptibility of patients in End Stage Renal Disease (ESRD) to viral and bacterial infections, their weak responses to vaccination and increased risk of malignant tumors and cardiovascular disease. It is important to underline that these immune complications mainly affect patients on dialysis. The mechanisms of these immunological disturbances observed in ESRD patients are still unclear. Early identification of chronic kidney disease allows implementing interventions to slow the progression to ESRD. Therefore, measures aimed at attenuating immune abnormalities in ESRD should be a main research area as this could lead to increased survival and better quality of life in HD patients.
Author Keywords: renal disease, innate immunity, adaptive immunity.
Lahcen Elmoumou1 and Hassan Fellah2
1 Immunology Laboratory, Faculty of Medicine and Pharmacy, Casablanca, Morocco
2 Immunology Laboratory, Faculty of Medicine and Pharmacy, Casablanca, Morocco
Original language: English
Copyright © 2016 ISSR Journals. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
The progressive loss of kidney function is associated with an inflammatory state and functional defects of the innate and adaptive immune system. The combined effects of increased activation and immune dysfunction could explain the susceptibility of patients in End Stage Renal Disease (ESRD) to viral and bacterial infections, their weak responses to vaccination and increased risk of malignant tumors and cardiovascular disease. It is important to underline that these immune complications mainly affect patients on dialysis. The mechanisms of these immunological disturbances observed in ESRD patients are still unclear. Early identification of chronic kidney disease allows implementing interventions to slow the progression to ESRD. Therefore, measures aimed at attenuating immune abnormalities in ESRD should be a main research area as this could lead to increased survival and better quality of life in HD patients.
Author Keywords: renal disease, innate immunity, adaptive immunity.
How to Cite this Article
Lahcen Elmoumou and Hassan Fellah, “The effect of end-stage renal disease on innate and adaptive immunity,” International Journal of Innovation and Applied Studies, vol. 18, no. 3, pp. 711–720, November 2016.
