Volume 41, Issue 4, February 2024, Pages 1298–1304
F. Samira Safaraliyeva1, B. Dilgam Taghıyev2, and A. Nizami Zeynalov3
1 Ph.D student ARESM Institute of Catalysis and Inorganic Chemistry Named After Acad.M.Nagiyev, Azerbaijan
2 Academician, Director ARESM of named after acad. M.Nagiyev Institute of Catalysis and Inorganic, Chemistry, Azerbaijan
3 Prof., Head of Department of «Nanostructured Metal-Polymer Catalysist», ARESM Institute Catalysis and Inorganic Chemistry named after Acad. M. Nagiyev Baku AZ1143, Azerbaijan
Original language: English
Copyright © 2024 ISSR Journals. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
The products obtained as a result of the simultaneous reaction of chitosan, a Schiff-based natural polyaminosaccharide, with formaldehyde and benzaldehyde were synthesized by the method indicated in the experimental part of the article. The two amine groups formed were then reduced with NaBH4 to give the corresponding tertiary amine derivative. The structure of the obtained product was characterized by scanning electron microscopy and elemental analysis was determined. The introduction of hydrophobic methyl and benzyl groups into the macromolecule of chitosan reduces the intermolecular interaction and hydrogen bonding. causes. This leads to an increase in the degree of polarization and better solubility of the functional groups of the product in the polar environment.
Author Keywords: N-Benzyl N-Methyl Chitosan, Alkylation, Polymers, Drug delivery, levotiroxin-Na pentahydrate, Arylation.
F. Samira Safaraliyeva1, B. Dilgam Taghıyev2, and A. Nizami Zeynalov3
1 Ph.D student ARESM Institute of Catalysis and Inorganic Chemistry Named After Acad.M.Nagiyev, Azerbaijan
2 Academician, Director ARESM of named after acad. M.Nagiyev Institute of Catalysis and Inorganic, Chemistry, Azerbaijan
3 Prof., Head of Department of «Nanostructured Metal-Polymer Catalysist», ARESM Institute Catalysis and Inorganic Chemistry named after Acad. M. Nagiyev Baku AZ1143, Azerbaijan
Original language: English
Copyright © 2024 ISSR Journals. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
The products obtained as a result of the simultaneous reaction of chitosan, a Schiff-based natural polyaminosaccharide, with formaldehyde and benzaldehyde were synthesized by the method indicated in the experimental part of the article. The two amine groups formed were then reduced with NaBH4 to give the corresponding tertiary amine derivative. The structure of the obtained product was characterized by scanning electron microscopy and elemental analysis was determined. The introduction of hydrophobic methyl and benzyl groups into the macromolecule of chitosan reduces the intermolecular interaction and hydrogen bonding. causes. This leads to an increase in the degree of polarization and better solubility of the functional groups of the product in the polar environment.
Author Keywords: N-Benzyl N-Methyl Chitosan, Alkylation, Polymers, Drug delivery, levotiroxin-Na pentahydrate, Arylation.
How to Cite this Article
F. Samira Safaraliyeva, B. Dilgam Taghıyev, and A. Nizami Zeynalov, “Synthesis and study of morphological structure of N-methyl, N-benzyl derivative of chitosan,” International Journal of Innovation and Applied Studies, vol. 41, no. 4, pp. 1298–1304, February 2024.
