Petrosolinum crispum (Apiaceae) is a plant commonly used in traditional African medicine for improving the health of populations including wound care; the aim of this study was to evaluate the healing properties of Petrosolinum crispum (Apiaceae) leaves on second degree incision wounds in Wistar rats. This study was carried out on 28 rats divided into 7 batches of 4 rats, one of which was an untreated control and the other 6 received daily applications of test substances. The results showed that the wounds treated with 500 mg/ml of the aqueous extract of leaves of Petrosolinum crispum (EAPc) healed first. At this concentration, the healing time is the same as that of rats treated with Flammazine, 16 days against. For the batches treated with Betadine and EAPc at 1000 mg/ml, the wounds had completely healed in 26 days. However, those of the untreated rats had healed 95% by the 28th day. This effect of the extract is due to the bioactive substances present within the plant. These results therefore suggest that this extract has healing activity.

This study aims to enhance the African pharmacopoeia, for this purpose, we undertook to evaluate the therapeutic efficacy of the aqueous extract of leaves of Petroselinum crispum (Apiaceae), a plant used in the treatment of anemia. Qualitative phytochemical tests carried out with this extract have revealed the presence of sterols, polyterpenes, polyphenols, catechic tannins, flavonoids, alkaloids, quinones and saponosides. The study of acute toxicity by gavage in female mice, according to the guidelines of the OECD-423 revealed that the extract is not toxic. Anemia was induced in Wistar rats by oral administration of phenylhydrazine hydrochloride. Gavage of anemic rats with an aqueous extract of leaves of Petroselinum crispum (Apiaceae), at 500 or 1000 mg/kg body weight or Ranferon® reference substance corrected the anemia after 14 days. Red blood cell count, hemoglobin, hematocrit, mean corpuscular volume, mean corpuscular hemoglobin content and mean corpuscular hemoglobin concentration impaired by phenylhydrazine were restored. At a dose of 1000 mg/kg, the extract was more effective than Ranferon®. It appears from this study that this extract has anti-anaemic properties in accordance with the effectiveness recognized in traditional medicine. This activity is similar to that of Ranferon® and would be due to the presence of phytochemicals it contains.

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