Volume 33, Issue 2, July 2021, Pages 426–434
Koulaï Diane1, Doumbia Idrissa2, Yeo Sounta Oumar3, M’boh Gervais Mélaine4, Kipré Gueyraud Rolland5, and Djaman Allico Joseph6
1 Food and Bioproducts Processes Laboratory, Agronomic, Forestry and Environmental Engineering Department, University of Man, PO Box 20 Man, Côte d’Ivoire
2 Food and Bioproducts Processes Laboratory, Agronomic, Forestry and Environmental Engineering Department, University of Man, PO Box 20 Man, Côte d’Ivoire
3 Food and Bioproducts Processes Laboratory, Agronomic, Forestry and Environmental Engineering Department, University of Man, PO Box 20 Man, Côte d’Ivoire
4 Biochemical Laboratory of Pasteur Institute of Ivory Coast, PO Box 490, Abidjan 01, Côte d’Ivoire
5 Biochemical Pharmacodynamic Laboratory, Biosciences Department, Felix Houphouet-Boigny University, PO Box 582, Abidjan 22, Côte d’Ivoire
6 Pharmacodynamics Biochemical Laboratory, UFR Biosciences, Felix Houphouet Boigny University, PO BOX, 582 Abidjan 22, Côte d’Ivoire
Original language: English
Copyright © 2021 ISSR Journals. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
The objective of this study was to perform triphytochemistry and to evaluate the effect of aqueous (AqE) and hydroethanol (EthE) extracts of Spathodeae campanulata on blood glucose and pancreatitis markers in streptozotocin (STZ) -induced diabetic male rats. S. campanulata P. beauv, is a plant belonging to the Bignoniaceae family which is traditionally used for the treatment of diabetes, malaria and schistosomiasis. In a first step, we performed triphytochemistry of the extracts which showed that the aqueous and hydroethanolic extracts of the barks are rich in polyphenols, flavonoids, saponosides, alkaloids, sterol-polyterpenes, tannins but relatively poor in quinones. In a second phase, this study consisted in evaluating the effects on glycaemia and markers of pancreatitis of AqE and EthE of S. campanulata administered to 46 male rats of the Wistar strain divided into 9 batches of four male rats made diabetic each by intraperitoneal injection of a single dose of 60 mg/kg/bw of STZ. After 28 days of treatment with 200, 400 and 800 mg/kg/bw of S. campanulata AqE and EthE, blood glucose, alpha amylase and lipase activities were significantly decreased with both extracts.
Author Keywords: Spathodea campanulata, blood glucose, pancreas marker, type 2 diabetes.
Koulaï Diane1, Doumbia Idrissa2, Yeo Sounta Oumar3, M’boh Gervais Mélaine4, Kipré Gueyraud Rolland5, and Djaman Allico Joseph6
1 Food and Bioproducts Processes Laboratory, Agronomic, Forestry and Environmental Engineering Department, University of Man, PO Box 20 Man, Côte d’Ivoire
2 Food and Bioproducts Processes Laboratory, Agronomic, Forestry and Environmental Engineering Department, University of Man, PO Box 20 Man, Côte d’Ivoire
3 Food and Bioproducts Processes Laboratory, Agronomic, Forestry and Environmental Engineering Department, University of Man, PO Box 20 Man, Côte d’Ivoire
4 Biochemical Laboratory of Pasteur Institute of Ivory Coast, PO Box 490, Abidjan 01, Côte d’Ivoire
5 Biochemical Pharmacodynamic Laboratory, Biosciences Department, Felix Houphouet-Boigny University, PO Box 582, Abidjan 22, Côte d’Ivoire
6 Pharmacodynamics Biochemical Laboratory, UFR Biosciences, Felix Houphouet Boigny University, PO BOX, 582 Abidjan 22, Côte d’Ivoire
Original language: English
Copyright © 2021 ISSR Journals. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
The objective of this study was to perform triphytochemistry and to evaluate the effect of aqueous (AqE) and hydroethanol (EthE) extracts of Spathodeae campanulata on blood glucose and pancreatitis markers in streptozotocin (STZ) -induced diabetic male rats. S. campanulata P. beauv, is a plant belonging to the Bignoniaceae family which is traditionally used for the treatment of diabetes, malaria and schistosomiasis. In a first step, we performed triphytochemistry of the extracts which showed that the aqueous and hydroethanolic extracts of the barks are rich in polyphenols, flavonoids, saponosides, alkaloids, sterol-polyterpenes, tannins but relatively poor in quinones. In a second phase, this study consisted in evaluating the effects on glycaemia and markers of pancreatitis of AqE and EthE of S. campanulata administered to 46 male rats of the Wistar strain divided into 9 batches of four male rats made diabetic each by intraperitoneal injection of a single dose of 60 mg/kg/bw of STZ. After 28 days of treatment with 200, 400 and 800 mg/kg/bw of S. campanulata AqE and EthE, blood glucose, alpha amylase and lipase activities were significantly decreased with both extracts.
Author Keywords: Spathodea campanulata, blood glucose, pancreas marker, type 2 diabetes.
How to Cite this Article
Koulaï Diane, Doumbia Idrissa, Yeo Sounta Oumar, M’boh Gervais Mélaine, Kipré Gueyraud Rolland, and Djaman Allico Joseph, “Triphytochemistry and effects of aqueous and hydro-ethanolic extracts of Spathodea campanulata P.beauv. (Bignoniaceae) on blood-sugar level and markers of pancreatitis in type 2 diabetic rats,” International Journal of Innovation and Applied Studies, vol. 33, no. 2, pp. 426–434, July 2021.
