[ Evaluation du profil lipidique au cours de l’hypothyroïdie: Expérience du laboratoire de biochimie, CHU Ibn Rochd de Casablanca, Maroc ]
Volume 35, Issue 1, December 2021, Pages 12–17
Hsai Fatima Ezzahra1, Asmaa Morjan2, Rachid El Faiz3, Mahir Loubna4, and Nabiha Kamal5
1 Laboratoire de biochimie, CHU Ibn Rochd, Faculté de Médecine et de Pharmacie, Université Hassan II, Casablanca, Morocco
2 Laboratoire de biochimie, CHU Ibn Rochd, Casablanca, Morocco
3 Laboratoire de biochimie, CHU Ibn Rochd, Faculté de Médecine et de Pharmacie, Université Hassan II, Casablanca, Morocco
4 Laboratoire de biochimie, CHU Ibn Rochd, Faculté de Médecine et de Pharmacie, Université Hassan II, Casablanca, Morocco
5 Laboratoire de biochimie, CHU Ibn Rochd, Casablanca, Morocco
Original language: French
Copyright © 2021 ISSR Journals. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Background: Hypothyroidism is among the most common endocrine disease; it is often associated with dyslipidemia which increases cardiovascular risk. This study was conducted to study the prevalence and profile of dyslipidemia during primary hypothyroidism and justify screening for dyslipidemia during hypothyroidism.Methods: Retrospective study, in the biochemistry department CHU Ibn Rochd of Casablanca from 2019 to March 2020 involving all patients who received a lipid assessment and a TSH (Thyroid Stimulating Hormone) assay in the biochemistry laboratory. TSH was estimated by an immunoenzymatic method: chemiluminescence. The LDL-assayed (Low Density Lipoprotein), HDL (High Density Lipoprotein), TG (Triglycerides), CT (Total Cholesterol) parameters were estimated by an enzymatic colorimetric method, the LDL-calculated was calculated by the friedwald formula.Results: These were 1046 patients: 66.73% Women, 33.23% Men (sex ratio M / F = 0.49). The mean age was 41.66 years ± 13.86. The mean TSH value was 23.09 mIU / L. Dyslipidemia was noted in 91.78% of cases.The prevalences of, hypoHDLemia, hypercholesterolemia, hypertriglyceridemia, hyperLDLemia, were respectively: 82.12%; 32.5%; 23.32%; 10.8%.The correlation between TSH and LDL was negative (P> 0.05) while it was positive with TG (P> 0.05), HDL (P <0.05) and CT (P> 0.05).Conclusion: Hypothyroid patients show a significant increase in serum lipids. This atherogenic lipid profile should be systematically sought when monitoring patients with hypothyroidism to prevent cardiovascular complications.
Author Keywords: Hypothyroidism, Lipid profile, Dyslipidemia, Prevalence, Cholesterol.
Volume 35, Issue 1, December 2021, Pages 12–17
Hsai Fatima Ezzahra1, Asmaa Morjan2, Rachid El Faiz3, Mahir Loubna4, and Nabiha Kamal5
1 Laboratoire de biochimie, CHU Ibn Rochd, Faculté de Médecine et de Pharmacie, Université Hassan II, Casablanca, Morocco
2 Laboratoire de biochimie, CHU Ibn Rochd, Casablanca, Morocco
3 Laboratoire de biochimie, CHU Ibn Rochd, Faculté de Médecine et de Pharmacie, Université Hassan II, Casablanca, Morocco
4 Laboratoire de biochimie, CHU Ibn Rochd, Faculté de Médecine et de Pharmacie, Université Hassan II, Casablanca, Morocco
5 Laboratoire de biochimie, CHU Ibn Rochd, Casablanca, Morocco
Original language: French
Copyright © 2021 ISSR Journals. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Background: Hypothyroidism is among the most common endocrine disease; it is often associated with dyslipidemia which increases cardiovascular risk. This study was conducted to study the prevalence and profile of dyslipidemia during primary hypothyroidism and justify screening for dyslipidemia during hypothyroidism.Methods: Retrospective study, in the biochemistry department CHU Ibn Rochd of Casablanca from 2019 to March 2020 involving all patients who received a lipid assessment and a TSH (Thyroid Stimulating Hormone) assay in the biochemistry laboratory. TSH was estimated by an immunoenzymatic method: chemiluminescence. The LDL-assayed (Low Density Lipoprotein), HDL (High Density Lipoprotein), TG (Triglycerides), CT (Total Cholesterol) parameters were estimated by an enzymatic colorimetric method, the LDL-calculated was calculated by the friedwald formula.Results: These were 1046 patients: 66.73% Women, 33.23% Men (sex ratio M / F = 0.49). The mean age was 41.66 years ± 13.86. The mean TSH value was 23.09 mIU / L. Dyslipidemia was noted in 91.78% of cases.The prevalences of, hypoHDLemia, hypercholesterolemia, hypertriglyceridemia, hyperLDLemia, were respectively: 82.12%; 32.5%; 23.32%; 10.8%.The correlation between TSH and LDL was negative (P> 0.05) while it was positive with TG (P> 0.05), HDL (P <0.05) and CT (P> 0.05).Conclusion: Hypothyroid patients show a significant increase in serum lipids. This atherogenic lipid profile should be systematically sought when monitoring patients with hypothyroidism to prevent cardiovascular complications.
Author Keywords: Hypothyroidism, Lipid profile, Dyslipidemia, Prevalence, Cholesterol.
Abstract: (french)
Introduction: L’hypothyroïdie est parmi les pathologies endocrines les plus fréquentes, elle est associée souvent à une dyslipidémie augmentant ainsi le risque cardiovasculaire. Cette étude a été menée pour étudier la prévalence et le profil de la dyslipidémie au cours de l’hypothyroïdie primaire, justifier le dépistage des dyslipidémies au cours de l’hypothyroïdie.Matériel Et Méthodes: Étude rétrospective, menée dans le service de biochimie CHU Ibn Rochd de Casablanca du janvier 2019 à mars 2020 intéressant tous les patients ayant bénéficié d’un bilan lipidique et d’un dosage de TSH (Thyroid Stimulating Hormone) au sein du laboratoire de biochimie. La TSH a été dosé par une méthode immunoenzymatique: la chimiluminescence. Les paramètres LDL-dosé (Low density lipoprotein), HDL (high density lipoprotein), TG (Triglycérides), CT (Cholestérol Total) ont été dosés par méthode enzymatique colorimétrique, le LDL-calculé a été calculé par la formule de friedwald.Résultats: Il s’agissait de 1046 patients: 66,73% Femmes, 33,23% Hommes (sex-ratio H/F=0,49). L’âge moyen était 41,66 ans±13,86. La valeur moyenne de TSH était à 23,09 mUI/L. Une dyslipidémie était notée dans 91,78% des cas.Les prévalences de, l'hypoHDLémie, l’hypercholestérolémie, l’hypertriglycéridémie, l'hyperLDLémie, étaient respectivement: 82.12%; 32,5%; 23.32%; 10.8%. La corrélation entre TSH et le LDL était négative (P>0.05) alors qu’elle était positive avec les TG (P>0.05), HDL (P<0.05) et CT (P>0.05).Conclusion: Les patients hypothyroïdiens présentent une augmentation significative des lipides sériques. Ce profil lipidique athérogène doit être recherché systématiquement lors du suivi des patients en hypothyroïdie pour prévenir les complications cardiovasculaires.
Author Keywords: Hypothyroïdie, Bilan Lipidique, Dyslipidémie, Prévalence, Cholestérol.
How to Cite this Article
Hsai Fatima Ezzahra, Asmaa Morjan, Rachid El Faiz, Mahir Loubna, and Nabiha Kamal, “Evaluation of the lipid profile in hypothyroidism: Experience of the biochemistry laboratory, CHU Ibn Rochd of Casablanca, Morocco,” International Journal of Innovation and Applied Studies, vol. 35, no. 1, pp. 12–17, December 2021.
