Branded drugs are more expensive than locally marketed drugs. The aim of this present study was to evaluate and compare dissolution pattern of locally branded drug products of Levocetirizine dihydrochloride of regional pharmaceutical companies available in Bangladesh with the reputed brand of Levocetirizine 2HCl (Purotrol®) marketed by Square pharmaceuticals Ltd. Four different brands of Levocetirizine 2HCl tablets and Purotrol® were collected from a reputed pharmacy store, then evaluated and compared subsequently. Five tablets from each of the brands were used for the in-vitro dissolution study. Cumulative drug release was measured up to 30 minutes for all the brands. Differential factor, f1 and similarity factor, f2 were determined. Significant difference was observed for in-vitro drug release pattern of local brands with respect to Purotrol®. Here it was found that the values of f1 are 25.11, 26.08 and 15.52 for brand B, C, and D respectively so it is not acceptable. Only brand A has f1 value less than 15 (13.7) therefore that is accepted. In case of similarity factor it was seen that the values of f2 are 44.79, 37.54, 30.77 and 16.27 for brand A, B, C, and D respectively, so it is also not acceptable. Significant difference was observed during in-vitro drug release pattern of B, C and D with from Purotrol®. Manufacturer of brand B, C, and D are advised to revise their drug release pattern to be more similar with Purotrol®.