Psychiatric manifestations may be a circumstance of discovery of hyperthyroidism, but may also contribute to delayed diagnosis. We report in this work, two clinical cases that confirm the richness of clinical manifestations and sometimes the delay to diagnosis in our socio-cultural context. These were two 52-year-old and 48-year-old patients with psychomotor agitation syndrome, severe anxiety, and delusional persecution syndrome, all of which occurred on goiter. In both cases, the thyroid assessment showed a collapsed TSH and elevated thyroid hormones, confirming the diagnosis of hyperthyroidism. The evolution was favorable under synthetic antithyroid and neuroleptics. Both patients subsequently benefited from subtotal thyroidectomy with simple operative follow-up. Multidisciplinary care, psychiatry and internal medicine were provided in both cases.