Pipeline vibration due to reciprocating compressors is a major problem faced by Oil and Gas industries worldwide. We present a method to reduce the pipeline vibration of 2HD/1 opposed-balanced reciprocating compressor. Vibrational readings are recorded for two of the reciprocating compressors in the plant (ONGC-Uran); Compressor A with major vibration in discharge pipeline and compressor B with vibration within acceptable limits so as to find the source of vibration in compressor A. As per the layout, pipeline design of reciprocating compressor A is done in SolidWorks software. Vibrational analysis of the pipeline by varying the external support locations is carried out using Ansys software. From the study, it is understood that the pressure pulsation in pulsation dampener is the primary reason for pipeline vibration. A suggestion for the vibration reduction is made by adding supports to alter the frequency of the pipeline. We conclude that for overall system performance and vibration reduction, anti-vibration measures as suggested should be implemented.