The traditional de-noising method used by classical hardware equipments can’t achieve successful de-noising effect and the software-only method never meets a high real time capability. Based on the Undecimated Wavelet Transform (UWT) which is an effective technique for de-noising signals corrupted by non-stationary noises, we propose implementing the UWT method on the field programmable gate array (FPGA) to realize a digital electronic circuit to de-noise the airflow of mechanical ventilation. The experiment results obtained was done regarding signal to noise ratio (SNR) and the requirement of real-time signal processing.