The geological, magnetic and mineralogical studies have uncovered a polymetallic mineralization deposit at Amensif in the Amezmiz mining district (western High Atlas, Morocco). The Cu, Pb, Zn, Ag and Au mineralizations are hosted in the Lower Cambrian volcano-carbonate formations. These formations are structurally controlled by Hercynian faults (NE-SW, ENE-WSW, E-W and NW-SE). These hercynian faults were facilitated the circulation of hydrothermal fluid that responsible for the implementation of the economically mineralization. The hydrothermal alterations having affected the Lower Cambrian volcano-carbonate formations of Amensif are in mutual relations with the genesis of the Cu, Pb, Zn, Ag and Au polymetallic mineralizations. Mineralogical study of this deposit reveals the presence of a particular and characteristic mineral assemblages composed of chalcopyrite, sphalerite, galena, arsenopyrite, pyrite, grey copper, minor amount of silver, gold and bismuth. Microtextural relationship between the sulphides indicates sulphureted these mineralizations result from two distinct stages paragenetic: (I) an arseno-ferriferous stage and (II) a polymetallic stage. The estimated reserves based on the analyses of samples collected from 25 drill cores established in the sector go back to 568 110 Tons of ore with 3.79% Zn, 0.69% Pb, 1.02% Cu, 98.30ppm Ag and 0.48 ppm Au. The geological setting, lithofacies, mineral assemblages, geochemical analyses and a mode of hydrothermal alteration remind those described in certain "High-temperature polymetallic Carbonate Replacement Deposits" type worldwide.