Typhoid fever remains, today, a major public health problem worldwide with a universal estimate of 12 to 33 million annual cases. It is caused by a strictly human species, Salmonella typhi, discovered since 1880 by Eberth.Typhoid fever has long been the cause of human disasters across the world: in the 17th century, for example, 600 people died from this disease in James Towen in Virginia (USA).Indeed, the defective hygienic conditions of our immediate environment place S. typhi at the first rank of the main causes of food poisoning, typhoid fever is also the main disease of « dirty hands ».Formerly effective, most antibiotics have shown their limits: which leads researchers to turn to plants (traditional medicine) to assess their sensitivity to salmonella typhi.Costus afer has been used in certain regions as a medicinal decoction against hemorrhoids and liver diseases for a long time, we thought to test in vitro its activity against S. typhi.Of this research, 67% of the typhus strains tested were sensitive below 3%, the strains became resistant: 33% for greatly reduced concentrations.