Weeds represent one of the main constraint responsible for the proliferation of pests in cassava cultivation. It generally serves as hosts of parasites and pests. It impacts negatively the management process of these. The study on the main noxious weeds in cassava cultivation in Me Region, in South-East of Côte d’Ivoire carried out using two field methods. The first was to undertake a survey among 206 cassava producers and the second, to carry out floritic surveys in the fields of the producers surveyed. A total of 23 recurrent weeds were obtained from they survey. Regarding floritic survey, out 176 weed species recorded, 8 have high potential for harmfulness. In descending ordre, there are: Porophyllum ruderale, Panicum laxum, Chromolaena odorata, Calopogonium mucunoides, Croton hirtus, Centrosema pubescens, Pueraria phaseoloides et Diodia rubricosa. The similarity coefficient of these two floristic lists showed that there is a floristic homogeneity between them (Cs=72.34 pc.). This study on the main binding weeds is proving to be te fundamental step in the implementation of an effective technical ways for the managment of cassava cultivation.