One of the acute complications of diabetes is diabetic ketoacidosis characterized by an increase in blood acidity and the formation of ketone bodies which are toxic to the body. It is from this understanding that we evaluated the impact of the consumption of a functional water-soluble salt formulated from sodium bicarbonate «Bicarbon-Plus» in alloxan induced diabetic rats. For this purpose, 4 batches of 8 rats of the Wistar strain were used. Anthropometric and biochemical parameters were accessed, as well as physiological tolerance. Bicarbon-Plus significantly reduced blood sugar and ketone levels in diabetic rats. The lost of lot of weight was observed in the diabetic rats that did not received Bicarbon-Plus. An increase in HDL-C levels was observed from the 14th to the 36th day in diabetic rats that consumed the Bicarbon-Plus. The diabetic rats having consumed 0.250 mL/100 g of b.w. Bicarbon-Plus, the ALT level decreased significantly, and the AST level was not significant compared to the diabetic control group. A decrease in creatine and urea levels was observed in diabetic rats that consumed Bicarbon-Plus. And diabetic rats that consumed Bicarbon-Plus have showed an extremely significant decrease in CRP levels, and an extremely significant increase in SOD levels. So Bicarbon-Plus is alkalizing, lowers ketonemia, hypoglycemic, increases HDL-C, anti-inflammatory, antioxidant, hepatoprotective, nephroprotective, and protects the mass of the pancreas. It is safe, and could be recommended for the treatment of diabetes.

Medicinal plants are widely used in Africa, especially in rural areas, to meet primary health care needs. Among them Massularia acuminata (Rubiaceae) is mainly used for its aphrodisiac properties.In order to verify its acute toxicity, a single dose of 5000 mg/kg body weight (bw) of the ethanolic extract of the stems of this plant was administered to a group of 10 female rats. The control group, also consisting of 10 female rats, received only distilled water. During the 14 days observation, all clinical signs and deaths were reported. At the end of the study, the LD50, blood hematological and biochemical parameters, and hepatic and renal histological examination were performed.The results showed that the administration of the ethanolic extract of the stems of Massularia acuminata did not modify the behavior of the rats and the estimated LD50 was higher than 5000 mg/kg bw. The evaluation of hematological and biochemical parameters revealed a significant decrease (p <0.05) in the level of white blood cells and platelets, and a significant increase (p <0.05) in creatinine and total cholesterol. As for the histological study, apart from some hepatic apoptosis, the result did not show any hepatic and renal lesions.This study showed that the ethanolic extract of the stems of Massularia acuminata could exhibit hematotoxicity, nephrotoxicity and hepatotoxicity when higher doses were used.