Introduction: The World Health Organization (WHO) ranks allergies as the fourth most common chronic disease. Food allergie, defined as adverse immune reactions to food proteins, is an important public health problem that affects adults and children and may be increasing in prevalence. The aim of our study is to present the biological profile of children consulting for food allergy problems. Materials and methods: Retrospective descriptive study, spread over a period of 29 months. Concerning 177 children consulting for type I hypersensitivity problems at the CHU Ibn Rochd. Results: 109 children (61.5%) had sensitization to at least one trophallergen. It was more frequent in boys than in girls (54% vs 46%) without statistically significant difference (p= 0.27). The most frequent food allergens in our series were: sesame 21.47%, cow’s milk 20.90%, egg white 19.21%, crab 18.08%, beef 16.38%, casein 12.43%. Total IgE was ordered for 46 patients with a median of 202.3 KU, L. 30 (65%) children had elevated total IgE and 16 (35%) children had normal total IgE, with an increase in median total IgE concentration with the number of specific IgE to which a child is sensitized. Conclusion: Our study showed a high prevalence of sensitization to food allergens in children. Larger and more in-depth studies are needed to better understand the risk factors and mechanisms underlying food allergy in children in order to develop more effective and personalized prevention and treatment strategies.

Factor V deficiency by acquisition of an inhibitor is a rare pathology whose cause is often idiopathic. The clinical phenotype can range from asymptomatic laboratory abnormalities to life-threatening bleeds. We report a case of acquired factor V deficiency diagnosed in our laboratory, which illustrates the diagnostic procedure and the etiological circumstances. Acquired factor V inhibitors develop in extremely rare cases via the development of alloantibodies or autoantibodies against factor V. Several diseases or conditions are associated with factor V inhibitors. In this observation, the predisposing factor was the autoimmune context; our patient has ulcerative colitis. The biological diagnosis of factor V inhibitors (aFVi) remains a challenge, which every biologist must think about when faced with an isolated FV deficiency not explained by hepatic involvement. It is a rare pathology but its occurrence is worrying for both the biologist and the clinician because of the absence of a validated therapeutic strategy.

The lysosomal overload diseases constitute a heterogeneous group of rare constitutional diseases. In Morocco, these diseases remain very rare and under diagnosed. The diagnosis of certainty rests on enzymatic assay which can be long and difficult, unlike the discovery of a cytological anomaly thus allowing a fast tracking and early care management, hence the importance of the study of these pathologies at pediatric age and the installation of a register of rare pathologies. This present work aims to describe four clinico-biological observations of the overload diseases diagnosed in our laboratory.