Foliar diseases affecting rainfed barley in Mexico are mainly net blotch, spot blotch and leaf scald, which demerit the physical quality of grains. Current varieties are not resistant; thus, chemical control is an option to complement genetic control. This study aimed to determine the biological effectivity of fungicides to control foliar diseases and their effect on grain yield. The locations and crop seasons to conduct the study were in Tlaxcala and Puebla in 2019, respectively. The experimental design was a randomized complete block design in a split-plot arrangement with four reps. The main plot consisted of two varieties (Esmeralda and Doña Josefa), while sub-plots were two fungicides (Azoxistrobin 7.07 % plus Propiconazole 11.79 % and Propiconazole 25.64 %). Field measurements included days to heading and maturity, grain yield, test weight, and final disease severity (a visual score for disease control). The analysis of variance indicated significant differences (p≤0.01) between varieties, grain yield, and final disease severity. Disease control was more effective due to Azoxistrobin 7.07 % plus Propiconazole 11.79 %. Grain yield was more significant with fungicide application, overall Doña Josefa with Propiconazole 25.64 % (5972.38 kg ha-1). Field observations indicated that the application of Azoxistrobin lengthens the cropping season delaying the senescence (stay-green). Results suggested that chemical control of foliar diseases in barley is a suitable option.