The objective of this study is to measure the state of health of the population of Morocco regarding carbon monoxide (CO) poisoning based on the evolution over time and space of health indicators. A retrospective analytical study of health indicators related to carbon monoxide poisoning, i.e. incidence, mortality, and lethality at the regional and national population level during the period 1999 to 2013. The evolution over time of the incidence shows continuous growth at the national level. The highest average is thus observed in the region of Meknes-Tafilalt (0.112 per 1000 inhabitants). Regarding mortality indicators, the evolutionary study reveals overall continuous growth over time at the national level. At the regional level, we note annual fluctuations in rates in virtually all regions and case fatalities record the highest averages in the regions of Fez-Boulmane, Gharb-Chrarda-Beni Hssen, Rabat-Salé-Zemmour-Zaer, Doukkala-Abda, and Souss-Massa-Draa. The study highlights, on the one hand, that CO poisoning in Morocco is mainly influenced by weather conditions. Indeed, regions characterized by autumn and especially cold winter temperatures record the highest incidences. On the other hand, the fatal risk in the event of poisoning does not depend on the incidence at the level of regional populations, and the chronological evolution of mortality and case fatality rates at the national level is rather dependent on the unforeseeable accidental nature of the occurrence of deaths.