Objectives: To evaluate occupational risks at the Abass Ndao Hospital Center. Methodology: This was an observational, descriptive study conducted in internal medicine in July 2021. Data collection was based on direct interviews and observation of work situations using a pre-established questionnaire containing all the parameters of PRRA in a hospital environment. Results: Out of 118 agents, the sex ratio (M/F) was 0.66 and the average age was 36.49 years. Our agents were medical (35.6%) and support staff (64.4%). Biological products were handled in 35.6% and 38.1% used sharp equipment and recapping was practiced in 31.6%. AES were reported in 9.3% and Covid-19 infection in 8.4%. About 87.2% reported awkward postures. Musculoskeletal disorders were reported in 68.6%, handling of heavy loads in 77.1% and electrical risk in 90.7%. The agents were exposed to irritating (100%), corrosive (60%), toxic (33%) and flammable (100%) products, mainly by the cutaneous, respiratory and ocular routes. Approximately 33.8% of the workers suffered from varying degrees of professional stress and 67.8% declared that they were victims of violence, especially verbal violence. Only 5% said that their remuneration met their expectations. Conclusion: Work-related nuisances are frequent, varied and of varying severity in health facilities. It is urgent to implement corrective and preventive actions to ensure the health and safety of workers and patients.