There are 3 markets with good sanitation in Padang City and 5 with passable sanitation; the rest of the markets in Padang City did not meet the requirements, one of which was Padang Great Market. This is the largest central market in Padang City, but it still does not meet the requirements. This study aims to determine factors related to Padang Great Market Sanitation in 2023. Methods. The research used a quantitative approach cross-sectional design in January-April 2023 at Padang Great Market, using a questionnaire of 104 respondents. The sampling technique used proportional random sampling. Data processing using univariate analysis and bivariate analysis using a chi-square test with a degree of confidence of 95% (α = 0.05). Results. Univariate analysis showed 47.1% of sanitation was not good, 68.3% of traders traded full-time, 49% had fewer roles, and 40.4% of sanitation workers still lacked support. Bivariate analysis showed that there was a significant relationship (p<0.05) between the duration of trading time (p=0.000), the role of traders (p=0.000), support of cleaners (p=0.000), and Padang Great Market Sanitation. Conclusion. Duration of trading time, traders’ role, and cleaning staff support are related to Padang Great Market sanitation. Efforts to overcome this include educating traders and training cleaners about good market sanitation.