One of the most common types of risk faced by SMEs of the hotel sector in Cameroon is the operational risk as there exist uncertainty related to personnel, clients, processes and systems that motivated this study. Today, organizations are investing a lot on business activities which requires risk management practices to mitigate the negative outcomes of operational risks. In line with this, the study focuses on the effect of operational risk management on the profitability of Small and Medium Size Enterprises (SMEs) of the hotel sector in Cameroon. The data used was collected through questionnaires and limited to SMEs of the target sector, imputed through SPSS and analyzed by multiple correlations with ANOVA tables. The findings reveals that there exist strong positive relationship between operational risk management and profitability. Hence, By managing enterprise-wide risk, the management will develop a unified picture of risk for decision-making and improve the organization’s ability to manage risk effectively which can enhance its profitability. This present research will give new insight to the researchers and will help them to consider the proposed model to implement and generalize in different settings.