Medicinal plants can be an important element in the treatment of metabolic and cardiovascular diseases involved in the development of metabolic syndrome (MetS). The objective of this work was to evaluate the knowledge of medicinal plants with antidiabetic, antihypertensive and slimming properties used by the populations of the N’Zi Region. Ethnobotanical surveys were conducted in this region with 554 households and 17 healers using a questionnaire. This study made it possible to inventory a total of 69 medicinal plants used against the components of MetS. With 33 species used in households and 56 species used by healers. Spondias mombin (FC= 5.68%), Bambusa vulgaris (FC= 4.55%) and Citrus limon (FC= 4.55%) are the best known among healers. Among the households visited, Persea americana (FC= 23.50%) and Phyllanthus amarus (FC=9,29%) was the best known. The results obtained in this study show that Ananas comosus, Citrus limon and Parkia biglobosa are used both in healers and in households to treat hypertension, type 2 diabetes and obesity. These results show that these plants could be used as improved traditional medicines and could be used in the treatment of certain components of MetS such as diabetes, hypertension and obesity.