A cross-sectional study was conducted from April to October 2023 along the downstream of River Nkam in Yabassi locality (Littoral-Cameroon). The objective was to determine parasite fauna, the prevalence, abundance, mean intensity and risk factors of parasitic infections in wild freshwater fishes as for their control during their successful domestication and conservation. A total of 151 fishes comprising 43 Ctenopoma petherici, 31 Clarias jaensis, 21 Parachanna obscura, 25 Chrysichthys nigrodigitatus and 31 Oreochromis niloticus randomly captured from the River Nkam were used for the determination of the parasitological indexes. The results showed an overall high prevalence of multiple infections of 72.85% of all the fish species by five groups of parasites (p<0.0001) namely monogeneans (61.53%), trematodes (18.54%), myxosporeans (19.90%), cestodes (2.83%) and nematodes (8.72%). Besides, the abundance and mean intensity of monogeneans infection were either low or average and not influenced by the fish species. The significance of the effect of the fish sex, size and weight on the infection by monogeneans depended on fish species. Fishes from the Nkam river should be quarantined and treated against parasites before farming.