Cotton yield decrease in Côte d’Ivoire are important because of the climate change and pest infestations. The target of this survey is to analyze the spatio-temporal dynamics of Intra-Seasonal Descriptors (ISD) of rainfall and the annual mean infestation levels (MILs) of two pests, Helicoverpa armigera and Jacobiella facialis, as well as their interactions. The analysis datas are mainly constituted of annual rainfall and entomological data of H. armigera and J. facialis covering the period 1971-2016. The spatio-temporal distributions of rainfall ISDs and pest MILs were statistically analyzed, mapped, and their interactions determined using Instat+ and Surfer 11 software. Outcomes showed an interannual variability in rainfall ISDs, with coefficients of variation exceeding 30%. For H. armigera, MIL peaks shifted from the South and Center (1995–2000) to the Center-East and North-East (2011–2016), with an overall declining trend in MILs, attributable to the adoption of the Insecticide Resistance Management Program (IRMP) in 1999. However, a recent increase in peak levels suggests that climatic conditions particularly reduced cumulative rainfall and fewer rainy days favor its development. Regarding J. facialis, MILs increased from 3 to 16 infested plants per 30 plants, due to the IRMP’s limited focus on this pest, with the infestation hotspot shifting from the North (1995-2000) to the North-East and Center-East (2011-2016). These results demonstrated the relevance of integrating climatic conditions into pest management strategies.