A study carried out at the INERA Mvuazi research center aimed to assess the influence of peel content in fresh cassava roots in order to recommend optimal methods for selecting high-performance clones, thereby reducing post-harvest losses due to peel. The aim was also to determine the genetic variability of varieties under selection at IITA/INERA Mvuazi with regard to their peel content. The results revealed that peels influence fresh weight of peeled roots and dry yield, with variations ranging from 20% to 25% and 18% to 27% respectively at 12 and 15 months after planting (MAP). Significant genetic variability was observed for peel content at 15 MAP, where the Rav variety showed a lower percentage of fresh peel (17.50±0.7%) compared to the MVZ 2008/0330 (267.50±10.6%), MVZ 2008/002 (217.50±24.7%), and OBAMA (205.00±28.2%) varieties. Despite these differences, dry yields remained similar for all varieties. At 15 MAP, the ranking of varieties according to unpeeled fresh root weight changed significantly after peeling. The Rav variety achieved a fresh peeled root weight of 825.00±7.0 kg per ton of unpeeled root, outperforming the OBAMA (795.00±28.2 kg), MVZ 2008/022 (782.50±24.7 kg), and MVZ 2008/0330 (732.50±10.6 kg) varieties, the latter having the lowest weight. In conclusion, we recommend that breeders and processors give preference to the Rav variety for the development of high-performance clones and processing into by-products, in order to minimize post-harvest losses linked to peelings.