The use of medicinal plants such as Garcinia kola in the treatment of several diseases, including those considered incurable, is becoming increasingly common throughout the world in general and in Africa (Ivory Coast) in particular. This popularity can be explained especially by the therapeutic properties attributed to these plants. The objective of this study is to evaluate the safety of Garcinia kola seed extract prepared with koutoukou on the renal function of Wistar rats. The animal and plant material consisted of adult albino rats and Garcinia kola (Guttifferea) seeds, respectively. The preparation of plant extracts, phytochemical screening, Acute Oral Toxicity (AOT), determination of the LD50, blood tests, histological sections, and statistical analyses were performed using standard and certified methods. The yield of koutoukou extract (EKGK) is the highest (30.4 ± 0.61%). Phytochemical screening of EKGK reveals the presence of sterols and polyterpenes, polyphenols, flavonoids, catechin tannins, saponosides, and alkaloids with an LD50 greater than 2000 mg/kg of PC. Urea and creatinine did not increase significantly on day 14, confirming the absence of alterations in the renal parenchyma. In view of these results, it appears that EKGK belongs to the class of non-toxic substances and contains bioactive compounds that may confer therapeutic properties. Consumption of this cocktail showed no deleterious effects on renal function, a vital organ that plays a crucial role in body homeostasis.