Mastectomy due to breast cancer leads to significant physical and psychological changes that affect women’s comfort, body image, and quality of life. Postoperative challenges such as pain, limited shoulder mobility, lymphedema, skin sensitivity, and the use of breast prostheses create specific clothing needs that are not adequately addressed by most commercially available bras. This study aimed to develop and evaluate a supportive bra based on functional and aesthetic design solutions suitable for the post mastectomy stage. The research followed descriptive and experimental approaches. A survey was conducted to identify the functional and aesthetic needs of women after mastectomy. Based on the findings, a bra was designed and implemented using bamboo fabric due to its softness, breathability, antibacterial properties, and moisture absorption. The design incorporated a full cup with an internal prosthesis pocket, adjustable wide straps, a supportive underband, ventilation features, and carefully integrated aesthetic elements. The implemented design was evaluated by specialists and members of the target group. The results showed statistically significant improvement in functional and aesthetic performance, with high levels of acceptance. The study highlights the importance of integrating functional efficiency with aesthetic value in supportive garment design to enhance comfort, confidence, and overall quality of life for breast cancer survivors.