In this paper we consider learning and forgetting effect of workers for flexible flowshop scheduling problem with sequence dependent setup times. The objective is to minimize the weighted sum of maximum completion time and maximum tardiness. The learning effect occurs when operator's (workers) skill increases after repeating similar job causing the decrease of processing time. On the other hand, forgetting effect occurs when an operator relearns the process after an interruption for a batch setup, machine maintenance or operator condition recovery, causing the increase of processing time.