Aquaculture supplies nearly half of the fish consumed worldwide. However, in Côte d’Ivoire, this sector remains underdeveloped despite abundant water resources, largely due to the poor quality of feed, which limits the growth and survival of fingerlings. This study compares the effects of three premixes (Fish Growth, Vitaflash, and GBX) on the growth and health of 1,200 Oreochromis niloticus fingerlings. The fingerlings were reared in hapas for 30 days in pond 1 at the Jean LOROUGNON GUÉDÉ University training farm in Daloa, using four test diets in duplicate: a control diet and three diets enriched with 2% premix. The fingerlings were fed three times daily. Water physicochemical parameters and fingerling growth metrics were recorded every two weeks. The pond water had an average temperature of 27.6°C, a pH of 7.5, and an average oxygen level of 5.5 mg/l. These results showed that these parameters were favorable for raising Nile Tilapia Oreochromis niloticus. Conserning the premixes, results indicated that the GBX premix yielded the best outcomes for mortality (2.8%), weight (20.5 g), and length (10.3 cm). While GBX appears to be the most effective premix. In summary, this study recommends the use of GBX in commercial feed formulations for Nile tilapia (Oreochromis niloticus).