Ebola is a severe viral disease that spreads in West Africa countries, whose a search of an effective Drug is a necessity. The VP30 protein is known as an essential activator of transcription for Ebola virus. In another, Oleuropein, Kaempferol, and Quercetin are a bio-active components, originally from several plants, and which are known by their ability of inhibiting viral transcription activators such HIV. In this context we tested in silico by molecular modeling the ability of these substrates to inhibit VP30 by Building in the active sites, and the application of new pharmaceutical compounds, although direct manipulation in vitro or in vivo is limited by the terms of Biosafety - it is reserved for laboratory level BSL-4 - which slow the search process. The Oleuropein, Kaempferol, and Quercetin components are linked with the active sites of VP30 with a free energy score estimated near -8Kacl / mol and an average distance of 1.8 angstrom. We conclude that Oleuropein, Kaempferol, and Quercetin components may be effective treatment for Ebola Virus and essentially Kaempferol which has very ambitious Pharmacodynamics and kinetic owners, the things that make the component to be a candidate to be an effective Drug. Other experimental studies in vitro and in vivo are required to confirm.