Background and aim: This study conducted to determine gastrointestinal parasite (GI) infection and evaluation of some heamatological changes in domestic animals . Methods: One hundred fecal samples and blood were collected (4 camels; 4 horse; 5donkey; 40 cattle; 26 sheep, 18 goats and 3 dogs). Results: Of the total samples examined,86 (86.0%) were found positive for GI parasites. The hematological changes recorded in sheep, goat and cattle infected by GI parasites show decrease in PCV, Hb, RBCs and Plasma protein while slight increase in WBCs. Prevalence of GI parasite infection was higher (96.15%) in sheep compared with cattle (85.0%) and goats (83.33%). High percentage of infection (100 % / 60%) in horse than donkey was recorded respectively. Significant difference (P<0.05) was recorded in prevalence of GI parasites among small age group when compared to adults in sheep goats and cattle. Parasites identified in this study includes protozoan Eimeria spp. (95.40%), Nematodes, as Strongyles type of eggs (86.20%), Strongyloides papillosus (47.12%), Parascaris eqiurum (4.59%) and Oxyrius equi (25.0%) . Cestodes (50.57%), as Monieza sp. (48.27%), Monieza expansa (52.38%) Monieza benedeni (47.61%) and Anaplocephalum sp.(2.29%). The percentage of Monieza expansa and Monieza benedeni in sheep was (55.0%), (45.0%) respectively and in Goat (66.66%), (33.33%) while in Cattle (30.0%), (70.0%) respectively. Mixed infection was detected in 73 (84.88%) while single infection was detected in 13 (15.11%) in domestic animals samples. Conclusion: Mixed infections and young age come in consideration as a cause of hematological changes in farm animals.