Turnover intentions can be reduced if the employees feel the organization have met their needs, through improving of psychological well-being. Employees' psychological well-being must be fulfilled, to get their best performance. This study aims to find out the relations between psychological well-being (i.e. autonomy, environmental mastery, positive relations with others, purpose in life, self-acceptance and personal growth) and turnover intention of hotel employees. The subjects were 212 hotel employees in Medan, Indonesia. Data were collected using turnover intention scale and psychological well-being scale. The result showed negative correlations between psychological well-being and turnover intentions towards hotel employees. To find out the determinants of turnover intention, a stepwise regression method was used. Based on the stepwise method used, the two predictor variables were found to be of significance in explaining turnover intentions. The two predictor variables were autonomy and positive relations with others. The result of this study will contribute to the guide lines for the policy makers for implementation of better human resource policy and provide evidence in favor of managerial interventions aimed at enhancing employee well-being and, consequently, minimizing the negative effects of an actual turnover in Hotel employee. Implication of this study could help management understand how to reduce the turnover intentions based on the employee and organization needs.