The human immunodeficiency virus (HIV) infection leading to Acquired Immunodeficiency Syndrome (AIDS) causes progressive decline in immunological response in people living with HIV/AIDS making them susceptible to a variety of and opportunistic infections which are responsible for morbidity and mortality. HIV patients are at high risk of opportunistic infection(OI).Among them Tuberculosis is common, Pnemocystis jirovecii pneumonia (PJP) is common with low CD4 count. Here we are describing a case of HIV-1 positive patient having low CD4 count. With multiple OI, it include PJP, Pulmonary tuberculosis and secondary bacterial pneumonia with Sphingomonas paucimobilis.