With the purpose of valorizing the Asteraceae family and ethnopharmacological heritage of the Meknes Tafilalet area in Morocco, an ethnobotanical study has been carried. A total of 344 interviews were done with out into the herbalists, traditional healers and druggists in the region of this area. This study enabled to inventory 48 exploited species belonging to 31 genera used to treat a variety of human diseases ; so, herbal remedies are often used to treat digestive disorders (18.6%), followed by the treatment of cardiovascular disorders (13.1%) and metabolic ones (12.5%). The leaves constitute the most used part (31.8%) and the most frequently employed modes of preparation for the majority of the remedies are the decoction (63.4%). Also, the species frequently used are : Anacyclus pyrethrum (11.6%), Dittrichia viscosa (7.6%) and Atractylis gummifera, Echinops spinosus and Calendula officinalis with 5.2 % each one.