Sodium alginate is one of such biodegradable polymers, which has been extensively exploited for the preparation of nanoparticles (NPs) for controlled delivery of several therapeutic agents. ICD-85 (venom derived peptides) has been shown to exhibit anti-cancer activity. In this report sodium alginate nanoparticles employed to improve upon its effectiveness. ICD-85 loaded NPs were prepared by ionic gelation method and were characterized by the particle size, zeta potential, transmission electron microscopy, FT-IR spectroscopy and in vitro release studies. The in vitro cytotoxicity was evaluated by MTT assay. TEM revealed ICD-85 loaded NPs to have spherical shapes with a size of approximately 200 nm. The zeta potential of the ICD-85 loaded NPs was estimated as
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