Objective: To identify the factors of risk that are in link with the disruption of the hepatic enzymes (GOT and GPT) at the PVVIH of the HGR FOMULAC Katana. Materials and methods: A transverse survey to analytic aim has been led on 150 PVVIH having frequented the HGR FOMULAC Katana during the active period of May 1st, 2011 to May 1st 2012. The data in relation with the biologic state of the PVVIH and the reasons of the disruptions of the transaminases have been collected and have been analyzed by means of software Epi Info version 3.5.1. The percentage, the average with deviation standard (DS) has been found and the doorstep of significance has been fixed to a p value < 0, 05. Results: The GOT transaminases and GPT were disrupted respectively to a rate of 14% and 11% at the aged PVVIH, of feminine sex, co infected by the viruses of B hepatitis and C, under ARV consuming the alcohol. Conclusion: The transaminases were disrupted at the PVVIH followed to the HGR katana. A good hold in load, the non-Consumption of alcohol and a regular control of the biologic parameters as the dosages of the hepatic enzymes, the serodiagnosis of B hepatitis and C could reduce the effects hepatotoxic by our PVVIH.