Introduction: This study analyzes hospital maternal death factors in six heath zones in the East of the Democratic Republic of Congo. The objective of this study is to identify the determinants and the circumstances of the maternal deaths. Methodology: This study is descriptive and analyzes the content of the medical files and death review of the mother deaths occurred between 2009 and June 2014 in 22 referral hospitals of 6 zones of health of the province of the North Kivu in the East of the RDC. The data collected by binomials of well experimented nurses and physician about 74 mother deaths were analyzed by SPSS software. Results: The hospital maternal mortality is high (106,9 deaths for 100.000 living Births). 87, 5% cases of maternal deaths arrived in time to the referral hospitals and 69,2% of cases were well taken in charge to the primary health level centers. On the other hand, the hospital care has been judged inadequate in 83,1 % of the cases, notably because of non-suitable medical and nursing care and limited availability either of the medicines and transfusion blood. The hemorrhage was the first reason of maternal death (63,4 % of the cases) and also the eclampsia (8,5%) and infections (7%). The indirect reasons were incriminated in less than 6% of the cases. Conclusion: The high level of hospital maternal deaths, the importance of the hemorrhages and limited medical and nurse competencies in maternal deaths, put in evidence the interest to reinforce the nurse and medical competencies and the clinical governance in reference hospitals.