Volume 8, Issue 4, October 2014, Pages 1842–1849
Khalid Balar1, Ilham Slassi2, Bouchra El Moutawakil3, Mariame El Messal4, Mustapha El Alaoui Faris5, Mohamed Yahyaoui6, Saadia Aidi7, Ahmed Adlouni8, Rachida Habbal9, and Sellama Nadifi10
1 Laboratory of Human Genetics and Molecular Pathology, University Hassan II, Faculty of Medicine, Casablanca, Morocco
2 Department of Neurology, Ibn Rochd University Hospital, Casablanca, Morocco
3 Department of Neurology, Ibn Rochd University Hospital, Casablanca, Morocco
4 Laboratory of Biochemistry, University Hassan II, Faculty of Sciences Ain chock, Casablanca, Morocco
5 Department of Neurology, Souissi University Hospital, Rabat, Morocco
6 Department of Neurology, Souissi University Hospital, Rabat, Morocco
7 Department of Neurology, Souissi University Hospital, Rabat, Morocco
8 Department of cardiovascular pathophysiology, University Hassan II, Faculty of Sciences Ben Msik, Casablanca, Morocco
9 Laboratory of Human Genetics and Molecular Pathology, University Hassan II, Faculty of Medicine, Casablanca, Morocco
10 Laboratory of Medical Genetics and Molecular Pathology, Faculty of Medicine and Pharmacy, Hassan II University, Casablanca, Morocco
Original language: English
Copyright © 2014 ISSR Journals. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
In this paper, we focus on the importance of interaction between adverse genetic mutations, and clinical risk factors in the development of ischemic stroke, knowing that this disease is multifactorial common that is affected by a number genetic mutations and environmental factors.
The apolipoprotein E4 allele (APO e4), Factor II G20210A prothrombin (blood clotting protein), and Factor V genotypes were examined in 165 patients with ischemic Stroke group and 165 Control group, at the Laboratory of Human Genetics and Molecular Pathology, University Hassan II- Faculty of Medicine in Casablanca and the department of neurology at the campus teaching hospital of Casablanca and Rabat. Logistics regression models and bivariate correlation analysis with Karl Pearson's method were used to estimate the role of co-occurrences of the clinical risk factors and genetic mutations in ischemic stroke.
The presence of the APO e4 is dominant in Stroke group than Control group and its association with hypertension, smoking and cholesterol increases the risk of ischemic stroke. FV mutation in association with hypertension or diabetes mellitus reveals a strong correlation in ischemic stroke. We found no significant relationship between the ACE D / D, FII, MTHFR 677TT genotype and clinical factors.
In some combinations, pairing of adverse genetic factors, which alone confer non-significant risk, with clinical risk factors can greatly increase the risk of having an ischemic stroke.
Author Keywords: Ischemic stroke, Clinical risk factors, Correlation, Logistic regression, Apolipoprotein E (ApoE), FV and Allele frequency.
Khalid Balar1, Ilham Slassi2, Bouchra El Moutawakil3, Mariame El Messal4, Mustapha El Alaoui Faris5, Mohamed Yahyaoui6, Saadia Aidi7, Ahmed Adlouni8, Rachida Habbal9, and Sellama Nadifi10
1 Laboratory of Human Genetics and Molecular Pathology, University Hassan II, Faculty of Medicine, Casablanca, Morocco
2 Department of Neurology, Ibn Rochd University Hospital, Casablanca, Morocco
3 Department of Neurology, Ibn Rochd University Hospital, Casablanca, Morocco
4 Laboratory of Biochemistry, University Hassan II, Faculty of Sciences Ain chock, Casablanca, Morocco
5 Department of Neurology, Souissi University Hospital, Rabat, Morocco
6 Department of Neurology, Souissi University Hospital, Rabat, Morocco
7 Department of Neurology, Souissi University Hospital, Rabat, Morocco
8 Department of cardiovascular pathophysiology, University Hassan II, Faculty of Sciences Ben Msik, Casablanca, Morocco
9 Laboratory of Human Genetics and Molecular Pathology, University Hassan II, Faculty of Medicine, Casablanca, Morocco
10 Laboratory of Medical Genetics and Molecular Pathology, Faculty of Medicine and Pharmacy, Hassan II University, Casablanca, Morocco
Original language: English
Copyright © 2014 ISSR Journals. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
In this paper, we focus on the importance of interaction between adverse genetic mutations, and clinical risk factors in the development of ischemic stroke, knowing that this disease is multifactorial common that is affected by a number genetic mutations and environmental factors.
The apolipoprotein E4 allele (APO e4), Factor II G20210A prothrombin (blood clotting protein), and Factor V genotypes were examined in 165 patients with ischemic Stroke group and 165 Control group, at the Laboratory of Human Genetics and Molecular Pathology, University Hassan II- Faculty of Medicine in Casablanca and the department of neurology at the campus teaching hospital of Casablanca and Rabat. Logistics regression models and bivariate correlation analysis with Karl Pearson's method were used to estimate the role of co-occurrences of the clinical risk factors and genetic mutations in ischemic stroke.
The presence of the APO e4 is dominant in Stroke group than Control group and its association with hypertension, smoking and cholesterol increases the risk of ischemic stroke. FV mutation in association with hypertension or diabetes mellitus reveals a strong correlation in ischemic stroke. We found no significant relationship between the ACE D / D, FII, MTHFR 677TT genotype and clinical factors.
In some combinations, pairing of adverse genetic factors, which alone confer non-significant risk, with clinical risk factors can greatly increase the risk of having an ischemic stroke.
Author Keywords: Ischemic stroke, Clinical risk factors, Correlation, Logistic regression, Apolipoprotein E (ApoE), FV and Allele frequency.
How to Cite this Article
Khalid Balar, Ilham Slassi, Bouchra El Moutawakil, Mariame El Messal, Mustapha El Alaoui Faris, Mohamed Yahyaoui, Saadia Aidi, Ahmed Adlouni, Rachida Habbal, and Sellama Nadifi, “Interaction and association between genetic mutations and clinical risk factors in developing ischemic stroke in Moroccan population,” International Journal of Innovation and Applied Studies, vol. 8, no. 4, pp. 1842–1849, October 2014.
