Volume 8, Issue 2, September 2014, Pages 556–566
Abdeltif Errouagui1, Hicham Charoute2, Noureddine Ghalim3, AbdelHamid Barakat4, Mostafa Kandil5, and Hassan Rouba6
1 Laboratoire de génétique moléculaire humaine, département de recherche scientifique, Pasteur Institute of Morrocco, place louis pasteur, Casablanca, Maroc
2 Laboratoire de génétique moléculaire humaine, département de recherche scientifique, Pasteur Institute of Morrocco, place louis pasteur, Casablanca, Maroc
3 Laboratoire de biochimie, centre de biologie médical, Pasteur Institute of Morrocco, place louis pasteur, Casablanca, Maroc
4 Laboratoire de génétique moléculaire humaine, département de recherche scientifique, Pasteur Institute of Morrocco, place louis pasteur, Casablanca, Maroc
5 Laboratoire des Sciences Anthropogenetiques et Pathologiques, Faculté des Sciences, Université Chouaib Doukkali, ElJadida, Maroc
6 Laboratoire de génétique moléculaire humaine, département de recherche scientifique, Pasteur Institute of Morrocco, place louis pasteur, Casablanca, Maroc
Original language: English
Copyright © 2014 ISSR Journals. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Vitamin D receptor (VDR) gene is recognized as candidate gene for susceptibility to several disease such cardiovascular disease, or arterial hypertension (AHT). The main objective of this study was to investigate a possible association between polymorphisms of the VDR gene and AHT among Moroccan patients. Materials and Methods: 177 clinically diagnosed AHT patients and 222 healthy controls from the Moroccans population were recruited. Bsm-I(rs1544410), Fok-I(rs10735810) and Apa-I (rs7975232) single nucleotide polymorphisms(SNPS) of VDR gene were analyzed using PCR-RFLP reaction. A Vitamin D level was determined using ELISA. Results: Fok-I polymorphism had a strong association with AHT in all genetics models. It was found that FF carriers tend to have higher HDL-c levels than the ff genotypes (55.30
Author Keywords: VDR gene, Polymorphisms, Haplotypes, Arterial hypertension, Morocco.
Abdeltif Errouagui1, Hicham Charoute2, Noureddine Ghalim3, AbdelHamid Barakat4, Mostafa Kandil5, and Hassan Rouba6
1 Laboratoire de génétique moléculaire humaine, département de recherche scientifique, Pasteur Institute of Morrocco, place louis pasteur, Casablanca, Maroc
2 Laboratoire de génétique moléculaire humaine, département de recherche scientifique, Pasteur Institute of Morrocco, place louis pasteur, Casablanca, Maroc
3 Laboratoire de biochimie, centre de biologie médical, Pasteur Institute of Morrocco, place louis pasteur, Casablanca, Maroc
4 Laboratoire de génétique moléculaire humaine, département de recherche scientifique, Pasteur Institute of Morrocco, place louis pasteur, Casablanca, Maroc
5 Laboratoire des Sciences Anthropogenetiques et Pathologiques, Faculté des Sciences, Université Chouaib Doukkali, ElJadida, Maroc
6 Laboratoire de génétique moléculaire humaine, département de recherche scientifique, Pasteur Institute of Morrocco, place louis pasteur, Casablanca, Maroc
Original language: English
Copyright © 2014 ISSR Journals. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Vitamin D receptor (VDR) gene is recognized as candidate gene for susceptibility to several disease such cardiovascular disease, or arterial hypertension (AHT). The main objective of this study was to investigate a possible association between polymorphisms of the VDR gene and AHT among Moroccan patients. Materials and Methods: 177 clinically diagnosed AHT patients and 222 healthy controls from the Moroccans population were recruited. Bsm-I(rs1544410), Fok-I(rs10735810) and Apa-I (rs7975232) single nucleotide polymorphisms(SNPS) of VDR gene were analyzed using PCR-RFLP reaction. A Vitamin D level was determined using ELISA. Results: Fok-I polymorphism had a strong association with AHT in all genetics models. It was found that FF carriers tend to have higher HDL-c levels than the ff genotypes (55.30
Author Keywords: VDR gene, Polymorphisms, Haplotypes, Arterial hypertension, Morocco.
How to Cite this Article
Abdeltif Errouagui, Hicham Charoute, Noureddine Ghalim, AbdelHamid Barakat, Mostafa Kandil, and Hassan Rouba, “Relationship with Vitamin D Receptor (RVD) Gene and Essential Arterial Hypertension in Moroccan Population,” International Journal of Innovation and Applied Studies, vol. 8, no. 2, pp. 556–566, September 2014.
