[ Chevauchement d’une hépatite chronique C et d’une hépatite auto immune: A propos d’un cas ]
Volume 25, Issue 4, March 2019, Pages 1285–1289
H. El Bayed Sakalli1, K. Ouazzani Touhami2, Brahim Takourt3, and J. El Bakouri4
1 Laboratoire d’Immuno-sérologie, CHU Ibn Rochd, Casablanca, Maroc
2 Laboratoire d’Immuno-sérologie, CHU Ibn Rochd, Casablanca, Maroc
3 Laboratoire d’Immuno-sérologie, CHU Ibn Rochd, Casablanca, Maroc
4 Laboratoire d’Immuno-sérologie, CHU Ibn Rochd, Casablanca, Maroc
Original language: French
Copyright © 2019 ISSR Journals. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Purpose: The hepatitis C-Auto-immune hepatitis overlap syndrome is an uncommon condition whose management can be difficult in both diagnosis and treatment. Patients et méthodes: 62 old years women, without particular history Hepatitis C was proven by a positive HCV viral load and the autoimmune hepatitis was proven by characteristic immunological and/or histological features.Liver function tests was prescribed. Search for hepatitis B and C viral markers was performed by chimiluminescence, the viral load of the virus VHC was performed by molecular biology. The nuclear anti body were detected by indirect immunofluorescence on hep cells 20-10.Solubles antigens was performed by dot blot Résults: Laboratory studies showed a lever transaminase ALAT at 220 UI /l, ASAT at 231 UI /l, hypergammaglobulineamia at 30g/l, HVC seropositive, high viral load at 6.19 106 UI/ml. The nuclear antibody showed cytoplasmic fluorescence, Anti DNA were negative, liver biobsy showed lymphocytic infiltrates and steatosis Conclusion: This case illustrates diagnostic and therapeutic difficulties of hepatitis C–AIH overlap syndromes, this study highlights the deciding contribution of the initial histological findings in the diagnosis of such a HCV/autoimmune hepatitis overlap syndrome.
Author Keywords: Hepatitis C, Autoimmune hepatitis, Overlap syndrome, nuclear antibody, hypergammaglobulineamia.
Volume 25, Issue 4, March 2019, Pages 1285–1289
H. El Bayed Sakalli1, K. Ouazzani Touhami2, Brahim Takourt3, and J. El Bakouri4
1 Laboratoire d’Immuno-sérologie, CHU Ibn Rochd, Casablanca, Maroc
2 Laboratoire d’Immuno-sérologie, CHU Ibn Rochd, Casablanca, Maroc
3 Laboratoire d’Immuno-sérologie, CHU Ibn Rochd, Casablanca, Maroc
4 Laboratoire d’Immuno-sérologie, CHU Ibn Rochd, Casablanca, Maroc
Original language: French
Copyright © 2019 ISSR Journals. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Purpose: The hepatitis C-Auto-immune hepatitis overlap syndrome is an uncommon condition whose management can be difficult in both diagnosis and treatment. Patients et méthodes: 62 old years women, without particular history Hepatitis C was proven by a positive HCV viral load and the autoimmune hepatitis was proven by characteristic immunological and/or histological features.Liver function tests was prescribed. Search for hepatitis B and C viral markers was performed by chimiluminescence, the viral load of the virus VHC was performed by molecular biology. The nuclear anti body were detected by indirect immunofluorescence on hep cells 20-10.Solubles antigens was performed by dot blot Résults: Laboratory studies showed a lever transaminase ALAT at 220 UI /l, ASAT at 231 UI /l, hypergammaglobulineamia at 30g/l, HVC seropositive, high viral load at 6.19 106 UI/ml. The nuclear antibody showed cytoplasmic fluorescence, Anti DNA were negative, liver biobsy showed lymphocytic infiltrates and steatosis Conclusion: This case illustrates diagnostic and therapeutic difficulties of hepatitis C–AIH overlap syndromes, this study highlights the deciding contribution of the initial histological findings in the diagnosis of such a HCV/autoimmune hepatitis overlap syndrome.
Author Keywords: Hepatitis C, Autoimmune hepatitis, Overlap syndrome, nuclear antibody, hypergammaglobulineamia.
Abstract: (french)
Introduction: Le chauvechement d’une hépatite virale C chronique et d’une hépatite auto-immune (HAI) représente une situation clinique peu commune dont la prise en charge peut s’avérer délicate tant sur le plan diagnostique que sur le plan thérapeutique. Patients et Méthodes: C’est une patiente âgée de 62 ans, sans antécédents particuliers, se présente avec une fièvre, un ictère, et une asthénie. Un bilan hépatique a été prescrit. La recherche des marqueurs des hépatites B et C virales est réalisé par chimiluminescence, la recherche de la charge virale du virus VHC a été réalisé par biologie moléculaire. Les anti corps anti nucléaires AAN sont détectés par Immunofluorescence Indirecte (II) sur des cellules Hep-20-10. Les antigènes solubles sont objectivés par dot blot. Résultats: Le bilan biologique décèle une ASAT a 231 UI /l et une ALAT a 220 UI /l, Une hypergammaglobulinémie à 30g/l, une sérologie positive de HVC, une charge virale élevée à 6.19 106 UI/ml, les anticorps anti nucléaires (AAN) ont montré une fluorescence cytoplasmique, les anti DNA étaient négatifs. La biopsie hépatique a objectivé des infiltrats lymphoplasmocytaires et une stéatose. Conclusion: nous illustrons par cette observation les difficultés diagnostiques d’un chauvechement d’ HAI hépatite C, montrant ainsi que l’anatomo-pathologie est d’un part décisif sur le plan diagnostic.
Author Keywords: Hépatite virale C, Hépatite auto-immune , Chevauchement, anti corps anti nucléaires, hypergammaglobulinémie.
How to Cite this Article
H. El Bayed Sakalli, K. Ouazzani Touhami, Brahim Takourt, and J. El Bakouri, “Overlap of Chronic Hepatitis C and Autoimmune Hepatitis: About a Case,” International Journal of Innovation and Applied Studies, vol. 25, no. 4, pp. 1285–1289, March 2019.
