[ Mélanome malin primitif du col : A propos d’un cas avec revue de la littérature ]
Volume 34, Issue 3, November 2021, Pages 506–512
H. Souradi1, Z. Bennani2, F. Amqrane3, Samia Tligui4, K. Fathi5, and N. Amrani6
1 Maternité Souissi, Université Mohamed V, Rabat, Morocco
2 Service de Gynécologie-Obstétrique, de Cancérologie et de Grossesses à Haut Risque, Maternité Souissi, Université Mohamed V, Rabat, Morocco
3 Service de Gynécologie-Obstétrique, de Cancérologie et de Grossesses à Haut Risque, Maternité Souissi, Université Mohamed V, Rabat, Morocco
4 Department of Gynecology-Obstetrics-Oncology and High-Risk Pregnancy, Souissi Maternity Hospital, Ibn Sina University Hospital Center, Rabat, Morocco
5 Service de gynécologie obstétrique cancérologie et grossesse à haut risque, Maternité Souissi-CHU Ibn Sina, Rabat, Morocco
6 Maternité Souissi, Université Mohamed V, Rabat, Morocco
Original language: French
Copyright © 2021 ISSR Journals. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Malignant melanoma of the female genital tract is rare, and its localization in the cervix is exceptional, it represents 3% of malignant melanomas of the female genital tract, At the initial stage of malignant melanoma of the cervix, the disease is limited to the cervical mucosa, subsequently it spreads locally via direct diffusion to adjacent organs, Clinically there are asymptomatic cases diagnosed during a routine examination, However, more often one has the presence of symptoms, because the cervix ulceration expands easily and become infected. The most common symptom is vaginal bleeding. Macroscopically, primary malignant melanoma presents variable appearances, The spectrum of cellular characteristics is broad, Immunohistochemical markers may be positive in primary cervical malignant melanoma such as S-100, HMB-45, Melan-A, Vimentin, and SOX10, Differential Diagnosis of Primary Malignant Melanoma of the Cervix requires the exclusion of metastatic malignant melanoma, or other primary neoplastic site, mainly dermal, Once the diagnosis of malignant melanoma of the cervix is confirmed, the full staging of the disease should be establishment. This is based on performing a tomography (whole-body CT) or a positron emission tomography (PET / CT), the determination of serum lactate dehydrogenase.The therapeutic approach is not standardized but is rather individualized according to the characteristics of the disease and the patient.
Author Keywords: Malignant melanoma, genital tract, cervix, ulceration, vaginal bleeding.
Volume 34, Issue 3, November 2021, Pages 506–512
H. Souradi1, Z. Bennani2, F. Amqrane3, Samia Tligui4, K. Fathi5, and N. Amrani6
1 Maternité Souissi, Université Mohamed V, Rabat, Morocco
2 Service de Gynécologie-Obstétrique, de Cancérologie et de Grossesses à Haut Risque, Maternité Souissi, Université Mohamed V, Rabat, Morocco
3 Service de Gynécologie-Obstétrique, de Cancérologie et de Grossesses à Haut Risque, Maternité Souissi, Université Mohamed V, Rabat, Morocco
4 Department of Gynecology-Obstetrics-Oncology and High-Risk Pregnancy, Souissi Maternity Hospital, Ibn Sina University Hospital Center, Rabat, Morocco
5 Service de gynécologie obstétrique cancérologie et grossesse à haut risque, Maternité Souissi-CHU Ibn Sina, Rabat, Morocco
6 Maternité Souissi, Université Mohamed V, Rabat, Morocco
Original language: French
Copyright © 2021 ISSR Journals. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Malignant melanoma of the female genital tract is rare, and its localization in the cervix is exceptional, it represents 3% of malignant melanomas of the female genital tract, At the initial stage of malignant melanoma of the cervix, the disease is limited to the cervical mucosa, subsequently it spreads locally via direct diffusion to adjacent organs, Clinically there are asymptomatic cases diagnosed during a routine examination, However, more often one has the presence of symptoms, because the cervix ulceration expands easily and become infected. The most common symptom is vaginal bleeding. Macroscopically, primary malignant melanoma presents variable appearances, The spectrum of cellular characteristics is broad, Immunohistochemical markers may be positive in primary cervical malignant melanoma such as S-100, HMB-45, Melan-A, Vimentin, and SOX10, Differential Diagnosis of Primary Malignant Melanoma of the Cervix requires the exclusion of metastatic malignant melanoma, or other primary neoplastic site, mainly dermal, Once the diagnosis of malignant melanoma of the cervix is confirmed, the full staging of the disease should be establishment. This is based on performing a tomography (whole-body CT) or a positron emission tomography (PET / CT), the determination of serum lactate dehydrogenase.The therapeutic approach is not standardized but is rather individualized according to the characteristics of the disease and the patient.
Author Keywords: Malignant melanoma, genital tract, cervix, ulceration, vaginal bleeding.
Abstract: (french)
Le mélanome malin de l’appareil génital féminin est rare, et sa localisation au niveau du col utérin est exceptionnelle, il représente 3 % des mélanomes malins du tractus génital féminin, Au stade initial du mélanome malin du col, la maladie est limitée à la muqueuse cervicale, par la suite, elle se propage localement via diffusion directe aux organes adjacents, Cliniquement il existe des cas asymptomatiques diagnostiqués lors d’un examen de routine, Cependant, le plus souvent, on a la présence de symptômes, car le col s'ulcère facilement et s’infecte. Le symptôme le plus fréquent est le saignement vaginal.Macroscopiquement, le mélanome malin primitif présente des aspects variables, Le spectre des caractéristiques cellulaires est large, Des marqueurs immuno histochimiques peuvent être positifs en cas du mélanome malin primitif du col comme S-100, HMB-45, Melan-A, Vimentin, et SOX10, le Diagnostic différentiel du mélanome malin primitif du col nécessite l'exclusion du mélanome malin métastatique, ou un autre site néoplasique primitif, principalement cutané, Une fois le diagnostic de mélanome malin du col est confirmé, la stadification complète de la maladie doit être mise en place. Cela repose sur la réalisation d’une tomographie (TDM corps entier) ou une émission de positons tomographique (PET/CT), le dosage des lactates déshydrogénase sérique.L'approche thérapeutique n'est pas standardisée mais est plutôt individualisé en fonction des caractéristiques de la maladie et la patiente.
Author Keywords: mélanome malin, tractus génital, le col cervical, ulcération, métrorragies.
How to Cite this Article
H. Souradi, Z. Bennani, F. Amqrane, Samia Tligui, K. Fathi, and N. Amrani, “Primary malignant melanoma of the cervix: Report of a case with review of the literature,” International Journal of Innovation and Applied Studies, vol. 34, no. 3, pp. 506–512, November 2021.
