[ Activité anti anémique d’un extrait aqueux de feuilles de Petroselinum crispum (Apiaceae) ]
Volume 39, Issue 3, May 2023, Pages 1452–1461
Virginie Atto1, Adépo Yapo Prosper2, and Brou Konan André3
1 Laboratoire de Physiologie, Pharmacologie, Unité de Formation et de Recherche Biosciences, Université Félix HOUPHOUËT-BOIGNY, Côte d’Ivoire
2 Laboratory of Biotechnology, Agriculture and Development of Biological Resources, Félix Houphouët-Boigny University, 22 BP 582 Abidjan Côte d’Ivoire
3 Laboratory of Biology and Health, Félix Houphouët-Boigny, University, 22 BP 582 Abidjan 22, Côte d’Ivoire
Original language: French
Copyright © 2023 ISSR Journals. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
This study aims to enhance the African pharmacopoeia, for this purpose, we undertook to evaluate the therapeutic efficacy of the aqueous extract of leaves of Petroselinum crispum (Apiaceae), a plant used in the treatment of anemia. Qualitative phytochemical tests carried out with this extract have revealed the presence of sterols, polyterpenes, polyphenols, catechic tannins, flavonoids, alkaloids, quinones and saponosides. The study of acute toxicity by gavage in female mice, according to the guidelines of the OECD-423 revealed that the extract is not toxic. Anemia was induced in Wistar rats by oral administration of phenylhydrazine hydrochloride. Gavage of anemic rats with an aqueous extract of leaves of Petroselinum crispum (Apiaceae), at 500 or 1000 mg/kg body weight or Ranferon® reference substance corrected the anemia after 14 days. Red blood cell count, hemoglobin, hematocrit, mean corpuscular volume, mean corpuscular hemoglobin content and mean corpuscular hemoglobin concentration impaired by phenylhydrazine were restored. At a dose of 1000 mg/kg, the extract was more effective than Ranferon®. It appears from this study that this extract has anti-anaemic properties in accordance with the effectiveness recognized in traditional medicine. This activity is similar to that of Ranferon® and would be due to the presence of phytochemicals it contains.
Author Keywords: Petroselinum crispum, phenylhydrazine, Anemia, Antianaemia, haematological parameters.
Volume 39, Issue 3, May 2023, Pages 1452–1461
Virginie Atto1, Adépo Yapo Prosper2, and Brou Konan André3
1 Laboratoire de Physiologie, Pharmacologie, Unité de Formation et de Recherche Biosciences, Université Félix HOUPHOUËT-BOIGNY, Côte d’Ivoire
2 Laboratory of Biotechnology, Agriculture and Development of Biological Resources, Félix Houphouët-Boigny University, 22 BP 582 Abidjan Côte d’Ivoire
3 Laboratory of Biology and Health, Félix Houphouët-Boigny, University, 22 BP 582 Abidjan 22, Côte d’Ivoire
Original language: French
Copyright © 2023 ISSR Journals. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
This study aims to enhance the African pharmacopoeia, for this purpose, we undertook to evaluate the therapeutic efficacy of the aqueous extract of leaves of Petroselinum crispum (Apiaceae), a plant used in the treatment of anemia. Qualitative phytochemical tests carried out with this extract have revealed the presence of sterols, polyterpenes, polyphenols, catechic tannins, flavonoids, alkaloids, quinones and saponosides. The study of acute toxicity by gavage in female mice, according to the guidelines of the OECD-423 revealed that the extract is not toxic. Anemia was induced in Wistar rats by oral administration of phenylhydrazine hydrochloride. Gavage of anemic rats with an aqueous extract of leaves of Petroselinum crispum (Apiaceae), at 500 or 1000 mg/kg body weight or Ranferon® reference substance corrected the anemia after 14 days. Red blood cell count, hemoglobin, hematocrit, mean corpuscular volume, mean corpuscular hemoglobin content and mean corpuscular hemoglobin concentration impaired by phenylhydrazine were restored. At a dose of 1000 mg/kg, the extract was more effective than Ranferon®. It appears from this study that this extract has anti-anaemic properties in accordance with the effectiveness recognized in traditional medicine. This activity is similar to that of Ranferon® and would be due to the presence of phytochemicals it contains.
Author Keywords: Petroselinum crispum, phenylhydrazine, Anemia, Antianaemia, haematological parameters.
Abstract: (french)
Ce présent travail vise à valoriser la pharmacopée africaine, à cet effet, nous avons entrepris d’évaluer l’efficacité thérapeutique de l’extrait aqueux de feuilles de Petroselinum crispum (Apiaceae), une plante utilisée dans le traitement de l’anémie. Les tests phytochimiques qualitatifs réalisés avec cet extrait ont permis de mettre en évidence la présence de stérols, de polyterpènes, de polyphénols, de tanins catéchiques, de flavonoïdes, d’alcaloïdes, de quinones et de saponosides. L’étude de la toxicité aiguë par gavage chez des souris femelles, selon les directives de l’OCDE-423 a révélé que l’extrait n’est pas toxique. L’anémie a été induite chez le rat Wistar par l’administration par voie orale de la phénylhydrazine hydrochloride. Le gavage des rats anémiés par l’extrait aqueux de feuilles de Petroselinum crispum (Apiaceae), à 500 ou 1000 mg/kg de PC ou du Ranferon® substance de référence a corrigé l’anémie au bout de 14 jours. Le nombre de globules rouges, les taux d’hémoglobine, d’hématocrite, le volume globulaire moyen, la teneur corpusculaire moyenne en hémoglobine et la concentration corpusculaire moyenne en hémoglobine détériorés par la phénylhydrazine ont été restauré. A la dose 1000 mg/kg de PC, l’extrait a été plus efficace que le Ranferon®. Il ressort de cette étude que cet extrait a des propriétés antianémiques en accord avec l’efficacité qui lui est reconnue dans la médecine traditionnelle. Cette activité est semblable à celle du Ranferon® et serait due à la présence de composés phytochimiques qu’il contient.
Author Keywords: Petroselinum crispum, phénylhydrazine, Anemia, Antianémique, paramètres hématologiques.
How to Cite this Article
Virginie Atto, Adépo Yapo Prosper, and Brou Konan André, “Anti-anemic activity of an aqueous extract of leaves of Petroselinum crispum (Apiaceae),” International Journal of Innovation and Applied Studies, vol. 39, no. 3, pp. 1452–1461, May 2023.
