The Dja Faunal Reserve has a significant role in environment/wildlife conservation because of the biodiversity it contains. However, competition between humans and animals for resources leads to human-wildlife conflicts. The overall objective of this study was to contribute to the improvement of human-wildlife conflicts management in the southwestern periphery of the Dja Faunal Reserve. A total of 95 peoples were interviewed in 8 villages using stratified random sampling. The aim was to collect information on the species responsible for the damage, the crops devastated, conflict causes, and impacts of human-wildlife conflicts. This study shows that the loss and fragmentation of wildlife habitats (57%), changes in feeding behaviour due to the proximity of plantations (39%) and the increase in the size of riparian populations (4%) are the main causes of human-wildlife conflicts. Majority of the conflicts were due to wildlife attacks on crops (91%) and often happened at night (70%). Rodents were the main animal species responsible for the damage including hedgehogs (20%), porcupines (18%) and palm rats (11%). The economic losses due to human-wildlife conflicts were estimated at 20 339 335 to 28 597 740 Franc CFA per year. Several suggestions were made, including raising public awareness of the ban on occupying reserved and classified areas, and revising law No. 94/01 to take into account the management of human-wildlife conflicts.