The main objective of this article is to analyze the determinants of innovation within agri-food SMEs in Cameroon. Our empirical analysis is based on secondary source data from the study on the analysis of the determinants of firm’s performance in francophone sub-Saharan Africa: the cases of Cameroon, Côte d'Ivoire and Senegal conducted in 2014 with the support of IDRC. The logistic regression analysis reveals that: R&D, size of the firm, and cooperation influence the innovative capacity of firms, but different forms of innovation must be taken into account. We also find that competition significantly influences the capacity of innovation, but that it acts by diminishing the capacity for innovation. Finally, we find that geographical location positively and significantly affects all forms of innovation. These results contribute in the understanding of the innovation phenomenon within agri-food companies.