This study aims at measuring the banking technical efficiency levels in the Middle East and North Africa MENA region from the period 2010-2014 over six 06 countries (KSA, Qatar, Kuwait, Jordan, Tunisia, Algeria) using the nonlinear Data Envelopment Analysis DEA model based on an unbalanced panel data of 66 banks (47 conventional banks and 19 Islamic banks). The results suggest that conventional banks are more technical efficient than Islamic banks under the Constant returns to scale assumption. However, the efficiency scores vary across the sample under the Variable return scale assumption which reflect the importance of the size and economies of scale in determining the overall banking efficiency in the region.