This work was aimed at investigating the impact of human capital-driven factors, personality-driven factors, and environmentally driven factors on the entrepreneurial potential of the students at the University of Professional Studies, Accra (UPSA), Ghana. With 188 respondents retrieved out of 249 questionnaires sent to Information Technology and Business Administration final year students of UPSA, Ghana, and using ordinal regression analysis, the following results were revealed: the “Entrepreneurial potential” of the students depends on their personality traits of “Need for achievement” and “Risk tolerance” and the human capital factor of “Entrepreneurship education and training”. “Entrepreneurship education and training” is the most significant predictor with a p-value of 0.004, followed by “need for achievement” with a p-value of 0.033, and then “risk tolerance” with a p-value of 0.036.