The links between cannabis and psychotic disorders are old. Indeed, several studies have shown a strong association between cannabis and schizophrenia.Objective - Our research aims to focus on the function of cannabis consumption which may express polymorphic psychic suffering among schizophrenic patients.Method - A qualitative and quantitative study was conducted among 61 schizophrenic patients. And the clinical study.Results - Static analysis and study case have showen that cannabis is the principal consumed substance after tobacco. In our population, 82% are cannabis users, 58% consume it regularly and 80% also consume other psychoactive substances (alcohol, psychotropics).It appears that schizophrenic is characterized by a set of parameters such as: the early start of consumption from adolescence, in particular the early age of first contact with cannabis, the vulnerable personality, the anxiety, dysfunctional environment. The use of the questionnaire showed that 58% of cannabis consumers say they smoke cannabis to alleviate psychological suffering.Conclusion - Subjects suffering froms chizophrenia hospitalized in the Arrazi psychiatric hospital are particularly vulnerable to cannabis consumption. It is not only used according to a more or less manifest need of the subject, but also as an attempt to defend anesthesia and to avoid psychic suffering in a form of self-medication.