Introduction: This study aims to describe the perceptions of stakeholders involved in the management of the twelfth Ebola virus disease outbreak in North Kivu; in order to identify the contributing factors of its containment and management in less than 3 months. Methods: This descriptive and cross-sectional study used interviews guided by comprehensive questionnaire among all the stakeholders involved in the management of the twelfth Ebola virus disease, including health managers, healthcare providers, community leaders, heath partners and any other actors involved in the emergency response to outbreaks. Data analysis was performed using IBM SPSS version 23.0 for both coding and statistical analyses of collected data. Results: Based on the perceptions of different stakeholders who compared the tenth and twelfth outbreaks, the management of the latter was characterized by fewer funding and training of staff; a better understanding of local socio-cultural variations and needs (97.2%, versus 9.1%; p<0,001), a clear tracking and follow-up of contacted and/or suspected cases (91.5% versus 66.7%; p<0,001), a greater community involvement and application of standard operating measures implemented by the emergency team (80.3% versus 66.7%; p<0,001); and a proper management of cases of Ebola virus disease (both confirmed, suspected or contacted) (94.1% versus 66.7%; p<0,001). Conclusions: Our findings reveal that the integrative approach response into the local health system, which strengthened community engagement and trust in the emergency response ‘teams, enabled the rapid containment of the twelfth Ebola virus disease outbreak in North Kivu, in Democratic Republic of Congo. This approach is part of a new paradigm compatible with the health system resilience.